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  4. Recombinant Mouse Homeobox protein Hox-D11 (Hoxd11)

Recombinant Mouse Homeobox protein Hox-D11 (Hoxd11)

  • 中文名称：
    小鼠Hoxd11重组蛋白
  • 货号：
    CSB-YP010683MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hoxd11重组蛋白
  • 货号：
    CSB-EP010683MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hoxd11重组蛋白
  • 货号：
    CSB-EP010683MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hoxd11重组蛋白
  • 货号：
    CSB-BP010683MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hoxd11重组蛋白
  • 货号：
    CSB-MP010683MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hoxd11
  • Uniprot No.：
  • 别名：
    Hoxd11; Hox-4.6; Hoxd-11Homeobox protein Hox-D11; Homeobox protein Hox-4.6; Homeobox protein Hox-5.5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-323
  • 氨基酸序列
    MYLPGCAYYV APSDFASKPS FLSQPSSCQM TFPYSSNLAP HVQPVREVAF RDYGLERAKW PYRGGGGGGA GGGGGGGPGG GGGGSGGYAP YYAAAAAAAA AAAAAEEAAM QRDLLPPAGR RPDVLFKAPE PVCGAPGPPH GPAAAASNFY SAVGRNGILP QGFDQFYEAA PGPPFAGPQP QPAPAPPQPE GAADKGDPKP GAGGGGGSPC AKATPGPEPK GAAEGGGGEG EGPPGEAGAE KSGGTVAPQR SRKKRCPYTK YQIRELEREF FFNVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKLN RDRLQYFTGN PLF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. expressed adjacent to the pisiform in late-stage embryonic limbs, supporting a role for Hox genes in growth plate specification PMID: 25279687
    2. analysis of the Hoxd11 duplication demonstrated that the Hoxd11 can perform some functions supplied by its paralogue Hoxa11, the defects in forelimb bones are corrected when extra copies of Hoxd11 are present in the Hoxa11 homozygous mutant background PMID: 12217321
    3. early posterior restriction of Hox gene products sets up an anterior-posterior prepattern, which determines the localized activation of Shh; this signal is then translated into digit morphological asymmetry by promoting the late expression of Hoxd genes PMID: 15192229
    4. Mice lacking all Hox11 activity fail to form metanephric kidney structures; when Hoxd11 is ectopically activated in the anterior mesonephros, we observe a partial transformation to a metanephric program of development. PMID: 18485340
    5. mutant analysis shows that Hoxd11, Hoxd12, and Hoxd13 genetically interact to form and sculpt the forelimb, a potential genetic milieu that may have been exploited by evolutionary adaptation PMID: 8620844
    6. mutants display anterior homoeotic transformation of sacrum and (non-homeotic) regional defects in forelimb skeleton that reflect temporal and structural colinearity of the HoxD genes PMID: 7925020

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 数据库链接：

    KEGG: mmu:15431

    STRING: 10090.ENSMUSP00000122582

    UniGene: Mm.207763