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  4. Recombinant Mouse Homeobox protein Meis1 (Meis1)

Recombinant Mouse Homeobox protein Meis1 (Meis1)

  • 货号：
    CSB-YP713910MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP713910MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP713910MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP713910MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP713910MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Meis1Homeobox protein Meis1; Myeloid ecotropic viral integration site 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-390
  • 氨基酸序列
    MAQRYDDLPH YGGMDGVGIP STMYGDPHAA RSMQPVHHLN HGPPLHSHQY PHTAHTNAMA PSMGSSVNDA LKRDKDAIYG HPLFPLLALI FEKCELATCT PREPGVAGGD VCSSESFNED IAVFAKQIRA EKPLFSSNPE LDNLMIQAIQ VLRFHLLELE KVHELCDNFC HRYISCLKGK MPIDLVIDDR EGGSKSDSED VTRSANLTDQ PSWNRDHDDT ASTRSGGTPG PSSGGHTSHS GDNSSEQGDG LDNSVASPST GDDDDPDKDK KRHKKRGIFP KVATNIMRAW LFQHLTHPYP SEEQKKQLAQ DTGLTILQVN NWFINARRRI VQPMIDQSNR AVSQGTPYNP DGQPMGGFVM DGQQHMGIRA PGPMSGMGMN MGMEGQWHYM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
  • 基因功能参考文献：
    1. the role of Meis1 in sensorimotor gating and in the dopaminergic systems modulating it, is reported. PMID: 28645892
    2. Results show Meis1 Is expressed in normal and aberrant ducts, pancreatic intraepithelial neoplasia, and pancreatic ductal adenocarcinoma and that its expression increases cell migration in pancreatic cancer through transcriptional activation of Mcam. PMID: 27583552
    3. the Hoxa9- and Meis1-associated upregulation of Flt3 is a passive event with regard to leukemia development in mice and with limited relevance to the AML pathology. PMID: 27617578
    4. we show that simultaneous deletion of Meis1 and Meis2 in presumptive lens ectoderm results in arrested lens development in the pre-placodal stage, and neither lens placode nor lens is formed. We found that in the presumptive lens ectoderm of Meis1/Meis2 deficient embryos Pax6 expression is absent PMID: 27918583
    5. Meis1 is a major regulator of sympathetic target-field innervation and Meis1 deficient sympathetic neurons die by apoptosis from early embryonic stages to perinatal stages. PMID: 26857994
    6. PCBP2 overexpression rescues the Meis1 effects of Akt-mTOR pathway and hypertrophy of cardiomyocytes. PMID: 26597775
    7. Data indicate roles of myeloid ecotropic viral integration site 1 protein (Meis1) in both megakaryopoiesis and erythropoiesis. PMID: 26986211
    8. Sequential binding of MEIS1 and NKX2-5 on the Popdc2 gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis. PMID: 26411676
    9. Pbx3 contributes to Hoxa9 leukemogenesis through stabilization of the Meis1 protein. PMID: 25911551
    10. data point to role of Meis1 in striatal development, also supported by reduced neuronal differentiation in the lateral ganglionic eminence of Meis1(-/-) embryos PMID: 26511239
    11. Meis1 is at the core of a genetic network implicated in eye patterning/microphthalmia. PMID: 26253404
    12. Data indicate that Meis homeobox 1 (MEIS1) is required for the maintenance of myeloid-lymphoid leukemia protein MLL-fusion gene leukemia, and hepatic leukemia factor (HLF)is a key downstream mediator of Meis1. PMID: 25740828
    13. Meis1 regulates epidermal stem cells and is required for skin tumorigenesis. PMID: 25013928
    14. Meis1 is potentially involved in the maintenance of postnatal thymic epithelial cell. PMID: 24594519
    15. deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesis PMID: 24809472
    16. Data indicate that loss of homeodomain transcription factor Meis1 leads to a depletion of hematopoietic progenitor cells from the bone marrow. PMID: 24498346
    17. vivo and in vitro analysis of a common SNP with small effect size showed allele-dependent function in the prospective basal ganglia representing the first neurodevelopmental region implicated in Restless Legs Syndrome. PMID: 24642863
    18. results suggest a previously unidentified role for C/EBPalpha in maintaining the proliferation required for Hoxa9/Meis1-mediated leukemogenesis PMID: 24958854
    19. we detected MEIS1 expression in primary cultures of in vivo differentiated cortical neurons and astrocytes PMID: 23756022
    20. Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis. PMID: 24578510
    21. results imply that crosstalk between Oct4 and Meis1a on mutual gene expressions is essential for the determination of NE from EC cells PMID: 23451132
    22. There is direct yet differential regulation of meis1 transcription by Gfi1b in distinct hematopoietic lineages. PMID: 23308270
    23. results identify Meis1 as a critical transcriptional regulator of cardiomyocyte proliferation and a potential therapeutic target for heart regeneration PMID: 23594737
    24. Data have demonstrated the presence of Meis, Pbx, and Prep proteins during early lineage segregation in mammals: Meis1, Meis3, Pbx1, Pbx2, Pbx3, and Prep1 in the mouse. PMID: 22987645
    25. Meis1 deletion led to the accumulation of reactive oxygen species in hematopoietic stem cells and decreased expression of genes implicated in hypoxia response. PMID: 23091297
    26. Loss of Meis1 results in down-regulation of both Hif-1 alpha and Hif-2 alpha in hematopoietic stem cells. PMID: 22995899
    27. overexpression of Meis1 repressed the development of early erythroid progenitors, acting in vivo at the megakaryocyte-erythroid progenitor stage to skew development away from erythroid generation and toward megakaryocyte development PMID: 22665933
    28. Data show that Meis1d, a Meis1 isoform, is expressed in colon. PMID: 21858198
    29. During normal differentiation the Hoxa cluster, Pbx1 and Meis1 predominated, with a marked reduction in the majority of Hox genes and Meis1 occurring during hematopoietic commitment. PMID: 21083428
    30. The C-terminal domain of MEIS1 confers to PKNOX1 an ectopic transactivating function that promotes leukemogenesis by regulating expression of genes involved in chromatin accessibility and cell cycle progression. PMID: 21900201
    31. Meis1 disrupts the genomic imprint of Dlk1 in a NUP98-HOXD13 leukemia model. PMID: 20739957
    32. GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, which in turn facilitates HOX-mediated transcription and transformation. PMID: 20541704
    33. Meis1 over expression is associated with defective cell-cycle entry and transcriptional regulation of cyclin D3 leading to leukemogenesis. PMID: 20237320
    34. Data show that during limb development, Pbx1 nuclear expression correlates with the Meis expression domain. PMID: 19247936
    35. Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1. PMID: 12082612
    36. We have isolated a Meis1a transgenic mouse line exhibiting recessive male-specific lethality and non-alcoholic fatty liver disease (NAFLD), which coincides with pubescence and is androgen-dependent. PMID: 12374767
    37. The mRNA level of this protein was elevated in limb buds after treatment with retinoic acid. PMID: 12397630
    38. transplantation of bone marrow cells cotransduced with NUP98-HOXD13 and the HOX cofactor Meis1 rapidly caused lethal and transplantable acute myeloid leukemia PMID: 12543865
    39. Hoxa9 and Hoxa7 as well as the Hox coregulators Meis1 and Pbx3 among the targets upregulated by MLL-ENL-ERtm in conditionally transformed cells PMID: 14701735
    40. Meis1 knockout mice embryos have hematopoietic, angiogenic and eye defects. PMID: 14713950
    41. MEIS C termini possess transcriptional regulatory domains that respond to cell signaling and confer functional differences between MEIS and PREP proteins PMID: 15654074
    42. transcription factor oncoprotein (Meis1) establishes expression of a tyrosine kinase oncoprotein (FLT3) PMID: 15755900
    43. Meis1 has a critical role in hematopoiesis and vascular patterning in the mouse embryo PMID: 15882575
    44. the transforming property of Meis1 is modulated by 3 conserved domains, namely the Pbx interaction motif (PIM), the homeodomain, and the C-terminal region PMID: 16469876
    45. These results suggest that c-Myb is essential but not sufficient for Hoxa9/Meis1 mediated transformation. PMID: 16507773
    46. Persistent transactivation by Meis1 replaces hoxa9 function in myeloid leukemogenesis models. PMID: 16648484
    47. Coexpression of the Hox cofactor Meis1a accelerates the Cdx4 AML phenotype and renders it fully penetrant. PMID: 17068127
    48. Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. PMID: 17942707
    49. Retinal progenitor cells (RPCs) in chicks and mice express two Hth-related proteins, Meis1 and Meis2. PMID: 18216174
    50. Novel collaboration between Icsbp deficiency and Meis1/Meis3 in the acceleration of chronic myeloid leukemia-like disease. PMID: 18223676

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  • 相关疾病：
    Meis1 serves as a site of viral integration in 15% of the tumors arising in BXH-2 mice that develop myeloid leukemia as a result of the expression of an ecotropic murine leukemia virus.
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/MEIS homeobox family
  • 组织特异性：
    Expressed at high levels in the lung with lower levels detected in the heart and brain. Expressed in pancreatic islets (beta-cells and non-beta-cells).
  • 数据库链接：

    KEGG: mmu:17268

    STRING: 10090.ENSMUSP00000099942

    UniGene: Mm.356578