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  4. Recombinant Mouse Homeobox protein TGIF2 (Tgif2)

Recombinant Mouse Homeobox protein TGIF2 (Tgif2)

  • 货号：
    CSB-YP803981MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP803981MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP803981MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP803981MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP803981MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tgif2; Homeobox protein TGIF2; 5'-TG-3'-interacting factor 2; TGF-beta-induced transcription factor 2; TGFB-induced factor 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-237
  • 氨基酸序列
    SDSDLGEDE GLLSLTGKRK RRGNLPKESV KILRDWLYLH RYNAYPSEQE KLSLSGQTNL SVLQICNWFI NARRRLLPDM LRKDGKDPNQ FTISRRGGKA SDVALPRGSS PSLLAVSVPA PTNMLSLSVC SMPLHSGQGE KPAAPFPQVE LESPKALVTP ASTLTLLTRA EAGSPTGGLF NTPPPTPPEQ DKDDFSSFQL LVEVALQRAA EMELQKQQEP APPLLHTPLP FVSENAK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
  • 基因功能参考文献：
    1. Studies indicate the reprogramming activity of TG-interacting factor 2 (TGIF2) and suggest a stepwise reprogramming paradigm. PMID: 28193997
    2. loss of Tgif1 causes axial patterning defects that are enhanced by mutations in Tgif2 PMID: 27187787
    3. Data show that loss-of-function mutations in both Tgif1 and Tgif2 result in a failure of gastrulation. PMID: 20040491
    4. TGIF2 has a wide but well controlled expression pattern during mouse development. PMID: 15749073
    5. The Tgif2 gene contains a retained intron, within the second coding exon. One splice variant encodes the full length 237 amino acid Tgif2, whereas the shorter form results in the removal of 39 codons from the centre of the coding region. PMID: 16436215
    6. TGIF2 is the molecular link between dorsoventral patterning of the endoderm and pancreatic specification. PMID: 18094028

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/TGIF homeobox family
  • 数据库链接：

    KEGG: mmu:228839

    STRING: 10090.ENSMUSP00000096745

    UniGene: Mm.315625