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  4. Recombinant Mouse Homeobox protein aristaless-like 4 (Alx4)

Recombinant Mouse Homeobox protein aristaless-like 4 (Alx4)

  • 货号：
    CSB-YP001647MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001647MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001647MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001647MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001647MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Alx4
  • Uniprot No.：
  • 别名：
    Alx4Homeobox protein aristaless-like 4; ALX-4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-399
  • 氨基酸序列
    MNAETCVSYC ESPAAAMDAY YSPVSQSREG SSPFRGFPGG DKFGTTFLSA GAKGQGFGDA KSRARYGAGQ QDLAAPLESS SGARGSFNKF QPQPPTPQPP PAPPAPPAHL YLQRGACKTP PDGSLKLQEG SGGHNAALQV PCYAKESNLG EPELPPDSEP VGMDNSYLSV KETGAKGPQD RASAEIPSPL EKTDSESNKG KKRRNRTTFT SYQLEELEKV FQKTHYPDVY AREQLAMRTD LTEARVQVWF QNRRAKWRKR ERFGQMQQVR THFSTAYELP LLTRAENYAQ IQNPSWIGNN GAASPVPACV VPCDPVPACM SPHAHPPGSG ASSVSDFLSV SGAGSHVGQT HMGSLFGAAG ISPGLNGYEM NGEPDRKTSS IAALRMKAKE HSAAISWAT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in skull and limb development.
  • 基因功能参考文献：
    1. Inactivation of ALX4/Alx4 causes lacrimal gland aplasia in both human and mouse. These results reveal a key role of Alx4 in mediating FGF-Shp2-FGF signaling in the neural crest for lacrimal gland development. PMID: 29028795
    2. novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice PMID: 25673119
    3. Alx4 genetically interacts with and Shh and Gli3 during genital tubercle formation. PMID: 23942202
    4. A mutagenesis study characterizes a polydactylous phenotype that is caused by a nonsense mutation in the Alx4 gene. PMID: 23979902
    5. Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4. PMID: 14512019
    6. the loss of the severe preaxial polydactyly characteristic of Gli3-/- limbs in double mutant embryos establishes that this type of polydactyly requires Alx4 function. PMID: 15968591
    7. Function and regulation of Alx4 in limb development entail complex genetic interactions with Gli3 and Shh. PMID: 16039644
    8. Alx4, is required for normal branching morphogenesis of the ductal epithelia during pubescent mammary gland development. PMID: 16916507

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  • 相关疾病：
    Defects in Alx4 are the cause of Strong luxoid (lst) phenotype. At heterozygosity lst is characterized by preaxial abnormalities of the hindfeet and, very rarely, of the forefeet. Homozygotes show preaxial polydactyly of all four limbs, reductions and duplications of the radius, absence of the tibia, craniofacial defects, reduction of the pubis, and dorsal alopecia.
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 组织特异性：
    Expressed in osteoblasts. Not expressed in brain, heart, intestine, kidney, liver, muscle, spleen and testis.
  • 数据库链接：

    KEGG: mmu:11695

    STRING: 10090.ENSMUSP00000047962

    UniGene: Mm.389389