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  4. Recombinant Mouse Immunoglobulin iota chain (Vpreb1)

Recombinant Mouse Immunoglobulin iota chain (Vpreb1)

  • 货号：
    CSB-YP025887MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP025887MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP025887MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP025887MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP025887MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Vpreb1
  • Uniprot No.：
  • 别名：
    Vpreb1; Immunoglobulin iota chain; Protein VPreB1; CD antigen CD179a
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-142
  • 氨基酸序列
    Q PMVHQPPLAS SSLGATIRLS CTLSNDHNIG IYSIYWYQQR PGHPPRFLLR YFSHSDKHQG PDIPPRFSGS KDTTRNLGYL SISELQPEDE AVYYCAVGLR SQEKKRMERE WEGEKSYTDL GS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.
  • 基因功能参考文献：
    1. Data show no autoantibody production was detectable in surrogate light chain (SLC) components VpreB/CD179a and lambda5/CD179b transgenic mice. PMID: 25523463
    2. VpreB probes the fitness of newly generated VH domains of IgH chains for later pairing with IgL chains, and its non-Ig part fixes the preBCRs on the surface. PMID: 22566564
    3. Mice triply deficient for VpreB1 show B cell developmental defects but functional allelic exclusion of the IgH locus. PMID: 12055243
    4. To identify the sequences that regulate lambda5 and VpreB1 expression during B cell development, the DNaseI hypersensitive sites in the lambda5-VpreB1 functional domain were mapped. PMID: 15950724
    5. Multiple receptor-dependent mechanisms operating at all stages of B cell development limit the contribution of B cells with Dmu heavy chain alleles to the repertoire. PMID: 18768866
    6. The epigenetic profile of immunoglobulin light chain (IgL) genes is strongly influenced by pre-B cell receptor signaling and by the differentiative stage of the progenitor lymphocytes. PMID: 19155482

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  • 亚细胞定位：
    Endoplasmic reticulum.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Only expressed by pre-B-cells.
  • 数据库链接：

    KEGG: mmu:22362

    STRING: 10090.ENSMUSP00000074537

    UniGene: Mm.57574