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  4. Recombinant Mouse Importin subunit alpha-8 (Kpna7)

Recombinant Mouse Importin subunit alpha-8 (Kpna7)

  • 货号：
    CSB-YP012489MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP012489MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP012489MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP012489MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP012489MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kpna7
  • Uniprot No.：
  • 别名：
    Kpna7; Importin subunit alpha-8; Karyopherin subunit alpha-7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-499
  • 氨基酸序列
    MATSKAPKER LKNYKYRGKE MSLPRQQRIA SSLQLRKTRK DEQVLKRRNI DLFSSDMVSQ ALVKEVNFTL DDIIQAVNSS DPILHFRATR AAREMISQEN TPPLNLIIEA GLIPKLVDFL KATPHPKLQF EAAWVLTNIA SGTSEQTRAV VKEGAIQPLI ELLCSPHLTV SEQAVWALGN IAGDCAEFRD CVISNNAIPH LINLISKGIP ITFLRNISWT LSNLCRNKDP YPSESAVRQM LPPLCQLLLH RDNEILADTC WALSYLTKGG KEYIHHVVTT GILPRLVELM TSSELSISIP CLHTIGNIVA GTDEQTQMAI DAGMLKVLGQ VLKHPKTSIQ VLAAWTMSNV AAGPRHQVEQ LLCNLLPILV DLLRNAELKV QKEVVCTVIN IATGASQDQL TLLAHSGILE PMLSLLSAPD LEVVIIVLDI ISYLLQHIDN LQEKKRLYFQ IEKFGGFEKI ECLQHHHNIS ISNSALDIIE KYFCEDGDGD SLPGPGLRV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions in nuclear protein import.
  • 基因功能参考文献：
    1. a decreased H7N9 influenza A virus polymerase activity when importin-alpha7 was silenced by siRNA, is reported. PMID: 28189564
    2. a novel importin alpha family member with distinct subcellular localization and nuclear localization signal binding characteristics PMID: 20701745
    3. knocking out of Kpna7 induced abnormalities of gene expression (dppa2, dppa4, and piwil2) and epigenetic modifications (down-regulation of histone H3K27me3). Biochemical analysis showed that KPNA7 interacts with KPNB1 (importin-beta1). PMID: 20699224
  • 亚细胞定位：
    Nucleus. Note=In MII-stage oocytes, localizes to the spindle.
  • 蛋白家族：
    Importin alpha family
  • 组织特异性：
    Expressed predominantly in ovary. Isoform 1 is the predominant form.
  • 数据库链接：

    KEGG: mmu:381686

    STRING: 10090.ENSMUSP00000106300

    UniGene: Mm.332837