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  4. Recombinant Mouse Inositol oxygenase (Miox)

Recombinant Mouse Inositol oxygenase (Miox)

  • 中文名称：
    小鼠Miox重组蛋白
  • 货号：
    CSB-YP865580MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Miox重组蛋白
  • 货号：
    CSB-EP865580MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Miox重组蛋白
  • 货号：
    CSB-EP865580MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Miox重组蛋白
  • 货号：
    CSB-BP865580MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Miox重组蛋白
  • 货号：
    CSB-MP865580MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Miox
  • Uniprot No.：
  • 别名：
    Miox; Aldrl6; RsorInositol oxygenase; EC 1.13.99.1; Aldehyde reductase-like 6; Myo-inositol oxygenase; MI oxygenase; Renal-specific oxidoreductase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-285
  • 氨基酸序列
    MKVDVGPDPS LVYRPDVDPE MAKSKDSFRN YTSGPLLDRV FTTYKLMHTH QTVDFVSRKR IQYGSFSYKK MTIMEAVGML DDLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG LLHDLGKIMA LWGEPQWAVV GDTFPVGCRP QASVVFCDST FQDNPDLQDP RYSTELGMYQ PHCGLENVLM SWGHDEYLYQ MMKFNKFSLP SEAFYMIRFH SFYPWHTGGD YRQLCSQQDL DMLPWVQEFN KFDLYTKCPD LPDVESLRPY YQGLIDKYCP GTLSW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. these findings highlight the epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy. PMID: 28208054
    2. MIOX under high glucose ambience exacerbates renal injury during the progression of diabetic nephropathy following the generation of excessive reactive oxygen species via an unexplored glucuronate-xylulose pathway. PMID: 26792859
    3. Data suggest that Miox expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of Miox activity is related to phosphorylation of serine/threonine residues. PMID: 26578517
    4. MIOX expression attenuated tubular damage and improved renal function. PMID: 25270067
    5. KSP-positive cells acquired the characteristics of each segment of renal tubular cells through tubular formation when stimulated with Wnt4. PMID: 23755150
    6. RSOR/MIOX modulates various downstream pathways affected by high-glucose ambience, and conceivably it plays a role in the pathobiology of tubulointerstitium in diabetic nephropathy. PMID: 20335317
    7. is developmentally regulated in kidney, exhibits a distinct spatiotemporal distribution, and probably plays a role in tubulogenesis. PMID: 11880337
    8. Molecular cloning and characterization of myo-inositol oxygenase as a 33kDa protein. PMID: 15504367
    9. RSOR activity is modulated by diverse mechanisms, and it is endowed with dual properties to channel glucose intermediaries, characteristic of hepatic aldehyde reductases, and to maintain osmoregulation, in diabetes. PMID: 16330753
    10. These results indicate that MIOX is found at lower levels in extra-renal tissues where diabetic complications, including nephropathy, neuropathy, retinopathy, and cataract, are frequently observed. PMID: 16332355
    11. Data demonstrate the formation of an antiferromagnetically coupled, high-spin diiron(III/III) cluster upon treatment of solutions of Fe(II) and MIOX with excess O(2) or H(2)O(2). PMID: 16634620
    12. MIOX can use a diiron(II/III) cluster as its catalytic cofactor, implying that it is a novel member of the non-heme diiron oxygenase family. PMID: 16634621
    13. The mouse enzyme has been cloned, expressed in Escherichia coli, purified and crystallized from sodium formate. PMID: 16880565
    14. It is proposed that this mode of iron coordination (i.e., bidentate mode to one iron atom) and interaction with a key lysine residue activate myo-inositol for bond cleavage. PMID: 17012379

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Myo-inositol oxygenase family
  • 组织特异性：
    Kidney specific. Renal proximal tubules.
  • 数据库链接：

    KEGG: mmu:56727

    STRING: 10090.ENSMUSP00000023282

    UniGene: Mm.158200