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  4. Recombinant Mouse Insulin-like growth factor 2 mRNA-binding protein 2 (Igf2bp2)

Recombinant Mouse Insulin-like growth factor 2 mRNA-binding protein 2 (Igf2bp2)

  • 中文名称：
    小鼠Igf2bp2重组蛋白
  • 货号：
    CSB-YP716282MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Igf2bp2重组蛋白
  • 货号：
    CSB-EP716282MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Igf2bp2重组蛋白
  • 货号：
    CSB-EP716282MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Igf2bp2重组蛋白
  • 货号：
    CSB-BP716282MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Igf2bp2重组蛋白
  • 货号：
    CSB-MP716282MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Igf2bp2
  • Uniprot No.：
  • 别名：
    Igf2bp2; Imp2; Vickz2Insulin-like growth factor 2 mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IMP-2; IGF-II mRNA-binding protein 2; VICKZ family member 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-592
  • 氨基酸序列
    MMNKLYIGNL SPAVTADDLR QLFGDRKLPL AGQVLLKSGY AFVDYPDQNW AIRAIETLSG KVELHGKIME VDYSVSKKLR SRRIQIRNIP PHLQWEVLDG LLAEYGTVEN VEQVNTDTET AVVNVTYMTR EEAKLAIEKL SGHQFEDYSF KISYIPDEEV SSPSPPHRAR EQGHGPGSSS QARQIDFPLR ILVPTQFVGA IIGKEGLTIK NITKQTQSRV DIHRKENSGA AEKPVTIHAT PEGTSEACRM ILEIMQKEAD ETKLAEEVPL KILAHNGFVG RLIGKEGRNL KKIEHETGTK ITISSLQDLS IYNPERTITV RGTIEACANA EIEIMKKLRE AFENDMLAVN QQANLIPGLN LSALGIFSTG LSVLPPPAGP RGVPPSPPYH PFATHSGYFS SLYPHHHFGP FPHHHSYPEQ ETVSLFIPTQ AVGAIIGKKG AHIKQLARFA GASIKIAPAE GPDVSERMVI ITGPPEAQFK AQGRIFGKLK EENFFNPKEE VKLEAHIRVP SSTAGRVIGK GGKTVNELQN LTSAEVIVPR DQTPDENEEV IVRIIGHFFA SQTAQRKIRE IVQQVKQQEQ RYPQGVAPQR SK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.
  • 基因功能参考文献：
    1. The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. PMID: 24755648
    2. results reveal a highly distinctive axonal enrichment of IMP2, show that it interacts with a network of axon guidance-related mRNAs, and reveal that it is required for normal axon pathfinding during vertebrate development. PMID: 27385015
    3. p62/IMP2 promotes hepatocarcinogenesis by an amplification of inflammation. PMID: 26426686
    4. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. PMID: 25863250
    5. p62/IGF2BP2-2 drives the progression of NAFLD through elevation of hepatic iron deposition and increased production of hepatic free cholesterol. PMID: 25548482
    6. Mice with a liver overexpression of insulin-like growth factor 2 (IGF2) mRNA-binding protein p62/IMP2-2/IGF2BP2-2 show elevated Ccl2 levels, which models all stages of non-alcoholic fatty liver disease. PMID: 24173291
    7. data demonstrate that the HMGA2-IGF2BP2 axis functions as a key regulator of satellite cell activation and therefore skeletal muscle development PMID: 23177649
    8. oncofetal insulin-like growth factor 2 mRNA-binding protein 2 (IMP2, IGF2BP2) regulates oxidative phosphorylation (OXPHOS) in primary glioblastoma (GBM) sphere cultures (gliomaspheres) PMID: 22899010
    9. Dual phosphorylation of IMP2 at the mTOR sites is evident in the mouse embryo, likely coupling nutrient sufficiency to IGF2 expression and fetal growth PMID: 21576258

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    RRM IMP/VICKZ family
  • 组织特异性：
    Expressed in oocytes, granulosa cells of small and growing follicles and Leydig cells of the testis (at protein level). Expressed in testis and ovary.
  • 数据库链接：

    KEGG: mmu:319765

    STRING: 10090.ENSMUSP00000097629

    UniGene: Mm.489442