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  4. Recombinant Mouse Interferon alpha-1 (Ifna1)

Recombinant Mouse Interferon alpha-1 (Ifna1)

  • 货号：
    CSB-YP355683MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP355683MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP355683MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP355683MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP355683MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ifna1; Interferon alpha-1; IFN-alpha-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-189
  • 氨基酸序列
    CDLPQTH NLRNKRALTL LVQMRRLSPL SCLKDRKDFG FPQEKVDAQQ IKKAQAIPVL SELTQQILNI FTSKDSSAAW NTTLLDSFCN DLHQQLNDLQ GCLMQQVGVQ EFPLTQEDAL LAVRKYFHRI TVYLREKKHS PCAWEVVRAE VWRALSSSAN VLGRLREEK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
  • 基因功能参考文献：
    1. These findings also identify STAT3 as a therapeutic target against viral infection and highlight it as an essential pathway component for endogenous and therapeutic IFN-alpha responsiveness. PMID: 27988795
    2. the close association between the increased proportion of CD180-negative B cells and the activation of IFN-alpha signaling in Systemic lupus erythematosus, is reported. PMID: 26277892
    3. IL-12 and IFN-alpha differentially program CD8 T cells to re-express distinct levels of PD-1 upon re-encountering Ag, resulting in IL-12-stimulated cells being less susceptible to exhaustion in the face of sustained tumor Ag. PMID: 23804712
    4. The expansion of CD8 T cells depends on type I IFN, type I IFN and IL-12 or is largely independent of the two cytokines. PMID: 22815848
    5. A spontaneous genomic duplication and frameshift mutation in the guanine exchange factor dedicator of cytokinesis 2 (Dock2) that has arisen in at least a subset of circulating Irf5(-/-) mice and inadvertently been bred to homozygosity. PMID: 22431588
    6. Knockdown of endogenous guanylate binding protein (GBP)4 increases IRF7-mediated IFN-alpha production, whereas overexpression of GBP4 has the opposite effect. PMID: 22095711
    7. protects against antigen-induced arthritis PMID: 21469099
    8. Data show that similar T cell expansion and serum IgG responses were observed in adenovirus (Adv)-IFN-treated WT and BAFF-deficient mice despite their disparate pathological and clinical responses. PMID: 21383240
    9. Studies in both mice and humans have demonstrated a role for IFN-alpha/beta in directly influencing the fate of both CD4(+) and CD8(+) T cells during the initial phases of antigen recognition. PMID: 21320124
    10. IFN-alpha enhances both the induction and maintenance of programmed cell death (PD)-1 expression on T cell receptor-engaged primary mouse T cells through association of IFN-responsive factor 9 (IRF9) with the IFN stimulation response element. PMID: 21263073
    11. This article reports the production of interferon alpha/beta (IFN-alpha/beta) by SJL/J mouse brain astrocyte cultures infected with Theiler's murine encephalomyelitis virus (TMEV). PMID: 20038206
    12. TLR ligands facilitate antibody response by inducing type I interferon (IFN), which in turn elicits rapid and significant amounts of antigen-specific IgG2c. PMID: 20566717
    13. These results demonstrate that mouse hepatitis virus is recognized by both RIG-I and MDA5 and induces IFN-alpha/beta through the activation of the IRF-3 signaling pathway. PMID: 20427526
    14. Sufficient IFN-alpha production by plasmacytoid dentritic cells is an important determinant of vaccine efficacy. PMID: 20065291
    15. B cell-mediated type I IFN induction depended on the transcription factor IRF3. PMID: 17925397
    16. The involvement of IRF1 and IRF2 in TLR2-mediated responses, was studied. PMID: 18652890
    17. Report that tumor-targeted interferon-alpha1 delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. PMID: 18835032
    18. It is likely that IFN-alpha plays a complex role in the etiology of type 1 diabetes. PMID: 19120292
    19. Collectively, these findings demonstrate that constitutive and LPS-induced type I IFN play significant roles in regulating the differences in phenotype and function between BMM and GM-BMM. PMID: 19406830
    20. Recombinant IFN-alpha treatment promotes monocyte chemoattractant protein (MCP)-1, MCP-5, and, to a lesser extent, MCP-3 production in the bone marrow during murocytomegalovirus infection. PMID: 19620305

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Alpha/beta interferon family
  • 数据库链接：

    KEGG: mmu:15962

    STRING: 10090.ENSMUSP00000092580

    UniGene: Mm.57127