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  4. Recombinant Mouse Interferon-induced guanylate-binding protein 2 (Gbp2)

Recombinant Mouse Interferon-induced guanylate-binding protein 2 (Gbp2)

  • 中文名称：
    小鼠Gbp2重组蛋白
  • 货号：
    CSB-YP897446MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gbp2重组蛋白
  • 货号：
    CSB-EP897446MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gbp2重组蛋白
  • 货号：
    CSB-EP897446MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gbp2重组蛋白
  • 货号：
    CSB-BP897446MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gbp2重组蛋白
  • 货号：
    CSB-MP897446MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Gbp2; Guanylate-binding protein 2; EC 3.6.5.-; GTP-binding protein 2; GBP-2; mGBP-2; mGBP2; Guanine nucleotide-binding protein 2; Interferon-induced guanylate-binding protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-586
  • 氨基酸序列
    MASEIHMSEP MCLIENTEAQ LVINQEALRI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG KRTGFSLGST VQSHTKGIWM WCVPHPKKAG QTLVLLDTEG LEDVEKGDNQ NDCWIFALAV LLSSTFIYNS IGTINQQAMD QLHYVTELTD LIKSKSSPDQ SGVDDSANFV GFFPTFVWTL RDFSLELEVN GKPVTSDEYL EHSLTLKKGA DKKTKSFNEP RLCIRKFFPK RKCFIFDRPA QRKQLSKLET LREEELCGEF VEQVAEFTSY ILSYSSVKTL CGGIIVNGPR LKSLVQTYVG AISNGSLPCM ESAVLTLAQI ENSAAVQKAI THYEEQMNQK IQMPTETLQE LLDLHRPIES EAIEVFLKNS FKDVDQKFQT ELGNLLVAKR DAFIKKNMDV SSARCSDLLE DIFGPLEEEV KLGTFSKPGG YYLFLQMRQE LEKKYNQAPG KGLQAEAMLK NYFDSKADVV ETLLQTDQSL TEAAKEVEEE RTKAEAAEAA NRELEKKQKE FELMMQQKEK SYQEHVKKLT EKMKDEQKQL LAEQENIIAA KLREQEKFLK EGFENESKKL IREIDTLKQN KSSGKC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
  • 基因功能参考文献：
    1. GBP2 can effectively regulate beta-glucan-induced maturation of DCs, thus suppressing the proliferation of T cells. PMID: 29089068
    2. This study demonstrated that Gbeta2 is important for neuronal migration, especially in the multipolar-bipolar transition. PMID: 28334111
    3. this study identified guanylate-binding proteins GBP2 and GBP5 as key activators of AIM2 during infection with F. novicida. PMID: 25774716
    4. This study begins to define the properties of mGBP-2 responsible for inhibiting cell spreading. PMID: 20950129
    5. Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication. PMID: 23248289
    6. the inducible multimerization of mGBP2 is dependent on a functional GTPase domain. PMID: 22730319
    7. IRGM proteins indirectly modulate the localization of GBP2 through a distinct mechanism from that through which they regulate IRG protein localization PMID: 21757726
    8. mGBP-2 inhibits TNF-alpha activation of endogenous Rac1 and constitutively activate Rac can restore NF-kappaB transcription in the presence of mGBP-2. This is a novel mechanism by which IFNs can inhibit the cytokine induction of MMP-9 expression. PMID: 21502320
    9. Both IFN-gamma and mGBP-2 also inhibit cell spreading initiated by platelet-derived growth factor treatment, which is also accompanied by inhibition of Rac activation by mGBP-2. PMID: 20505078
    10. inhibits replication of both vesicular stomatitis virus (VSV) and encephalomyocarditis virus (EMCV); a wild type GTP binding motif was not required for VSV inhibition but was required for inhibition of EMCV PMID: 15717119
    11. mGBP-2, confers resistance to paclitaxel-induced cytotoxicity without inhibiting multinucleation. PMID: 16914101
    12. The data support the assumption that the main role of STAT1 in activating gbp2 transcription is to provide transcriptionally competent chromatin, whereas the function of IRF1 may lie in directly contacting RNA polymerase II complexes. PMID: 17293456

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus membrane. Membrane; Lipid-anchor.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3-type GTPase family, GB1 subfamily
  • 数据库链接：

    KEGG: mmu:14469

    STRING: 10090.ENSMUSP00000132435

    UniGene: Mm.24038