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  4. Recombinant Mouse Interferon-inducible protein AIM2 (Aim2)

Recombinant Mouse Interferon-inducible protein AIM2 (Aim2)

  • 货号：
    CSB-YP845977MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP845977MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP845977MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP845977MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP845977MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Aim2; Gm1313; Ifi210Interferon-inducible protein AIM2; Interferon-inducible protein 210; Ifi-210; Interferon-inducible protein p210
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-354
  • 氨基酸序列
    MESEYREMLL LTGLDHITEE ELKRFKYFAL TEFQIARSTL DVADRTELAD HLIQSAGAAS AVTKAINIFQ KLNYMHIANA LEEKKKEAER KLMTNTKKRG TQKVENRSQA ENCSAASATR SDNDFKEQAA TEVCPQAKPQ KKQMVAEQEA IREDLQKDPL VVTVLKAINP FECETQEGRQ EIFHATVATE TDFFFVKVLN AQFKDKFIPK RTIKISNYLW HSNFMEVTSS SVVVDVESNH EVPNNVVKRA RETPRISKLK IQPCGTIVNG LFKVQKITEE KDRVLYGIHD KTGTMEVLVL GNPSKTKCEE GDKIRLTFFE VSKNGVKIQL KSGPCSFFKV IKAAKPKTDM KSVE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.
  • 基因功能参考文献：
    1. lentinan is suggested as an anti-AIM2 and anti-non-canonical inflammasome candidate despite its up-regulation of cytokine expression. PMID: 28465544
    2. Studies suggest that absent in melanoma 2 (Aim2) inflammasomes regulate neuronal morphology and influence behaviors. PMID: 27561456
    3. This study found that Aim2 knockout mitigates Abeta deposition in the cerebral cortex and hippocampus of 5XFAD mice. PMID: 28618410
    4. The AIM2 inflammasome amplifies signals of infection, triggering noncanonical activation of NLRP3. During infection, AIM2 and caspase-11 induced membrane damage, which was sufficient and essential for activating the NLRP3 inflammasome. PMID: 28746866
    5. AIM2 overexpression and inhibition were studied in ApoE-/- mice that were fed a high-fat diet. The results showed that high fat diet increases the expression of AIM2. PMID: 29510138
    6. Thus, we demonstrated that AIM2 could promote the progression of atherosclerotic plaque by increasing migration in VSMCs. PMID: 29448104
    7. AIM2 cytosolic DNA sensor may conjugate competitively with cytosolic Mycobacterium bovis DNA to restrict Mycobacterium bovis induced STING-TBK1-dependent autophagy activation and IFN-beta secretion. PMID: 27409673
    8. AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection. PMID: 26838050
    9. results suggest that the function of AIM2 is focused on the innate immune response, and AIM2 is a detrimental host factor for influenza-induced lung injury and mortality. PMID: 28424239
    10. this study shows that aim2-like receptors are dispensable for the type I interferon response to transfected DNA ligands, DNA virus infection, and lentivirus infection PMID: 27496731
    11. These results show for the first time that AIM2 plays an important anti-inflammatory, yet inflammasome-independent function in cardiomyocytes PMID: 27148820
    12. These results demonstrate a central role for the AIM2 inflammasome in preventing dysbiosis and intestinal inflammation through regulation of the IL-18/IL-22BP/IL-22 and STAT3 pathway PMID: 27524110
    13. AIM2 senses radiation-induced DNA damage in the nucleus to mediate inflammasome activation and cell death. PMID: 27846608
    14. Molecular docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein. PMID: 27037024
    15. A tissue-specific role for the AIM2 inflammasome as a sensor for endogenous DNA species in the course of a ligand-dependent autoinflammatory condition. PMID: 26114879
    16. AIM2 inflammsome is functionally redundant in the inflammasomemediated caspase-1 activation and IL-1beta production during P. aeruginosa infection. PMID: 26107502
    17. AIM2 reduced Akt activation and tumor burden in colorectal cancer models, while an Akt inhibitor reduced tumor load in Aim2(-/-) mice PMID: 26107252
    18. For the first time, this paper demonstrated that miR-223 acted to inhibit IL-1beta production via AIM2 pathway, suppressing Kupffer cells pro-inflammatory activation at the early stage of ALF. Thus, it played an important role in the pathogenesis of ALF. PMID: 25562161
    19. Study found that Aim2-deficient mice were hypersusceptible to colonic tumor development. Production of inflammasome-associated cytokines and other inflammatory mediators was largely intact in Aim2-deficient mice; however, intestinal stem cells were prone to uncontrolled proliferation. PMID: 26095253
    20. The comparison shows mouse AIM2 PYD domain adopts a unique alpha2-alpha3 helix conformation distinct from its human homologues, but similar to the pyrin domain of human NLRP10/PYNOD, which belongs to another family. PMID: 25888795
    21. these results reveal a specific requirement for IRF1 and GBPs in the liberation of DNA for sensing by AIM2 depending on the pathogen encountered by the cell. PMID: 25774715
    22. AIM2 responds to endogenous ligands in this setting and contributes to the arthritic phenotype through inflammasome activation. PMID: 25548216
    23. The Aim2 inflammasome directs maturation of the proinflammatory cytokines IL-1beta and IL-18 and an inflammatory form of cell death called pyroptosis. PMID: 25488991
    24. The AIM2 inflammasome is a critical molecular platform for regulating IL-1beta release and survival during acute CNS S. aureus infection. PMID: 24484406
    25. s hypothesize that while p202 was evolutionarily selected to limit AIM2-mediated inflammation in some mouse strains, the same mechanism contributes to increased interferon production and lupus susceptibility. PMID: 23850291
    26. AIM2 might act as an important DNA sensor and a potential biomarker for apopDNA-induced macrophage functional maturation and SLE disease PMID: 23479181
    27. The AIM2 inflammasome is involved in macrophage activation during infection with virulent Mycobacterium bovis strain. PMID: 23901081
    28. we report a novel immune evasion mechanism of M. tuberculosis that involves the ESX-1-dependent, direct or indirect, suppression of the host cell AIM2 inflammasome activation during infection. PMID: 23997220
    29. These data suggest that sublytic caspase-1 activity could delay the formation of stable AIM2 speck, an inflammasome complex associated with cell death. PMID: 23630667
    30. These findings demonstrate that AIM2 plays an important role in M. tuberculosis infection through the recognition of Mtb DNA. PMID: 22695634
    31. The AIM2/ASC complex acts as a novel caspase-8 activation platform and triggers apoptosis of infected Casp1KO macrophages. PMID: 22555457
    32. Data indicate tha AIM2 is abundantly expressed and inducible. PMID: 23045604
    33. AIM2 HIN-200 domain in complex with the 15 bp DNA crystallized in the cubic space group I23 or I2(1)3, with unit-cell parameter a = 235.60 A PMID: 22949200
    34. Data show that SdhA is required for preventing AIM2 inflammasome activation. PMID: 22474394
    35. a pathway activating DNA damage signaling plays an important independent role in detecting intracellular foreign DNA, thereby complementing the induction of IFN and activation of the AIM2 inflammasome PMID: 22140256
    36. Our observations demonstrate that cell type and gender-dependent factors differentially regulate the expression of the Aim2 and p202 proteins PMID: 21943709
    37. expression of Aim2 protein is required to maintain the expression of the Fcgr2b gene and also predict epistatic interactions between the Ifi200 genes and the Fcgr2b gene within the Nba2 interval PMID: 21551362
    38. essential for host defense against cytosolic bacteria and DNA viruses PMID: 20351692
    39. critical for innate immunity to Francisella tularensis PMID: 20351693
    40. Data demonstrate that the third detector senses bacterial DNA and identify it as Aim2. PMID: 20562263
    41. Wild-type Listeria monocytogenes were also found to lyse, albeit at low levels, and trigger AIM2-dependent pyroptosis. PMID: 20417169
    42. Data show that Knockdown of AIM2 significantly decreased the secretion of IL-1beta and IL-18 from L. monocytogenes-infected macrophages PMID: 20566831
    43. these data establish a role for DNA sensing through the AIM2 inflammasome in the detection of intracellularly replicating bacteria. PMID: 20333626
    44. show that macrophages from mice lacking absent in melanoma 2 (AIM2) cannot sense cytosolic double-stranded DNA and fail to trigger inflammasome assembly. PMID: 20457908
    45. study showed p202 is an inhibitor of DNA-induced caspase activation; conversely AIM2 was required for caspase activation by cytoplasmic dsDNA; work indicates HIN-200 proteins can act as pattern recognition receptors mediating response to cytoplasmic dsDNA PMID: 19131592
    46. observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1 PMID: 19158675
    47. identification of AIM2 as an important inflammasome component that senses potentially dangerous cytoplasmic DNA, leading to activation of the ASC pyroptosome and caspase-1 PMID: 19158676
    48. AIM2 is a candidate cytoplasmic DNA sensor which shows specificity for double-stranded DNA. PMID: 19158679

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    HIN-200 family
  • 数据库链接：

    KEGG: mmu:383619

    STRING: 10090.ENSMUSP00000119465

    UniGene: Mm.131453