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  4. Recombinant Mouse Interleukin-1 receptor-associated kinase 1-binding protein 1 (Irak1bp1)

Recombinant Mouse Interleukin-1 receptor-associated kinase 1-binding protein 1 (Irak1bp1)

  • 中文名称：
    小鼠Irak1bp1重组蛋白
  • 货号：
    CSB-YP863673MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Irak1bp1重组蛋白
  • 货号：
    CSB-EP863673MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Irak1bp1重组蛋白
  • 货号：
    CSB-EP863673MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Irak1bp1重组蛋白
  • 货号：
    CSB-BP863673MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Irak1bp1重组蛋白
  • 货号：
    CSB-MP863673MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Irak1bp1
  • Uniprot No.：
  • 别名：
    Irak1bp1; Aip70; Simpl; Interleukin-1 receptor-associated kinase 1-binding protein 1; IRAK1-binding protein 1; ActA-binding protein 70; PLK-interacting protein; Signaling molecule that associates with the mouse pelle-like kinase; SIMPL
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-259
  • 氨基酸序列
    MSLQPAPASR VFMELVPWAD RGRENHPISA AEAQPIGRRP HVAEAHPGAR EVHVSGAAEV SASPDRALVT VRVSSTKEVS AEAKKSVCRR LDYITQSLQQ QGFQAENVTV TKNIRRVENA YHMEAEVCIT FTEFGKMQNI CNFLVEKLDS SVVISPPEFY HTPGSVENLR RQACLVAVEN AWRKAQEVCD LVGQTLGKPL LIKEEETKDW EGQTDDHQLS RLPGTLTVQQ KIKSATIHAA SKVFITFEVK GKEKKKKHL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity.
  • 基因功能参考文献：
    1. SIMPL functions as a TNFalpha-dependent p65 co-activator by facilitating the recruitment of MED1 to p65 containing transcriptional complexes to control the expression of a subset of TNFalpha-induced genes. PMID: 23630580
    2. IRAK1BP1 functions through its effects on NF-kappaB as a molecular switch to bias innate immune pathways toward the resolution of inflammation PMID: 20534545
    3. Signals transduced through the tumor necrosis factor-alpha-tumor necrosis factor -receptor I-SIMPL(substrate that interacts with mouse pelle-like kinase) pathway support hematopoietic progenitor cell survival, growth and differentiation PMID: 19941935
    4. TNF-alpha activation of NF-kappaB dependent-gene expression requires nuclear relocalization of p65 as well as nuclear relocalization of SIMPL, generating a TNF-alpha-specific induction of gene expression. PMID: 15485901
    5. Hsp70/Hsc70 bind the intrinsically disordered amino-terminal region of SIMPL to stabilize the protein and thereby regulate its activity. PMID: 17233114
    6. IRAK1BP1 regulates transcription of a specific subset of Toll-like receptor responsive genes, producing an overall antiinflammatory profile PMID: 18268037

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    IRAK1BP1 family
  • 组织特异性：
    Expressed in testis, brain, kidney, liver and heart.
  • 数据库链接：

    KEGG: mmu:65099

    STRING: 10090.ENSMUSP00000108871

    UniGene: Mm.41415