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  4. Recombinant Mouse Interleukin-36 receptor antagonist protein (IL36RN)

Recombinant Mouse Interleukin-36 receptor antagonist protein (IL36RN)

Unavailable
  • 中文名称：
    小鼠IL36RN重组蛋白
  • 货号：
    CSB-AP003141MO
  • 规格：
    ￥6340
  • 其他：

产品详情

  • 纯度：
    >85% as determined by SDS-PAGE and HPLC.
  • 基因名：
    IL36RN
  • Uniprot No.：
  • 别名：
    IL36RN; Fil1d; Il1f5; Il1h3; Il1hy1; Interleukin-36 receptor antagonist protein; IL-36Ra; Interleukin-1 HY1; IL-1HY1; Interleukin-1 delta; IL-1 delta; Interleukin-1 family member 5; IL-1F5; Interleukin-1 homolog 3; IL-1H3; Interleukin-1-like protein 1; IL-1L1
  • 种属：
    Mus musculus (Mouse)
  • 来源：
    E.Coli
  • 分子量：
    16.9 kDa
  • 氨基酸序列
    VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    Untagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
  • 基因功能参考文献：
    1. Transcripts for IL-1F5 are significantly increased in the involved skin of bi- and monotransgenic mice compared with their C57BL controls. PMID: 21242515
    2. IL-1F5 has unique loop conformations for receptor binding specificity PMID: 12974628
    3. IL-1F5 mediates anti-inflammatory effects through its ability to induce interleukin-4 production, as a consequence of its interaction with orphan receptor single Ig IL-1R-related molecule (SIGIRR)/TIR8. PMID: 18284608
  • 亚细胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    IL-1 family
  • 组织特异性：
    Highly abundant in embryonic tissue and tissues containing epithelial cells.
  • 数据库链接：

    KEGG: mmu:54450

    STRING: 10090.ENSMUSP00000028360

    UniGene: Mm.29261