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  4. Recombinant Mouse Interstitial collagenase A (Mmp1a)

Recombinant Mouse Interstitial collagenase A (Mmp1a)

  • 货号：
    CSB-YP880620MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP880620MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP880620MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP880620MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP880620MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mmp1a
  • Uniprot No.：
  • 别名：
    Mmp1a; McolAInterstitial collagenase A; EC 3.4.24.7; Matrix metalloproteinase-1a; MMP-1a; Mcol-A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    97-464
  • 氨基酸序列
    YAIT HNNPRWTKTH LTYSILNYTP YLPKAVVEDA IARAFRVWSD VTPLTFQRVF EEEGDIVLSF HRGDHGDNNP FDGPNYKLAH TFQPGPGLGG DVHYDLDETW TNSSENFNLF YVTAHELGHS LGLTHSSDIG ALMFPSYTWY TEDFVLNQDD INRIQDLYGP SPNPIQPTGA TTPHPCNGDL TFDAITTFRG EVFFFKGRFY IRVNRFMPEP ELNLIGILWP NLPVKLDAAY EASMIDQVRY FKGSKVWAVQ EQSVLRGFPR DIHSFFGFPS NVTHIDAAVC EEETGKTYFF VDHMYWRYDE NTQSMDPGYP RLTAEDFPGI DDKVDDVFQK GENFYFFHQS VQHRFNLQIR RVDDSRDSST WFNC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. Able to degrade synthetic peptides and type I and II fibrillar collagen.
  • 基因功能参考文献：
    1. The difficulty to effectively maintain Mmp1a in the zymogen form may account for the tight control of Mmp1a expression and reduced expression in normal tissue as compared to inflammatory states or cancer. PMID: 24737602
    2. Stromal Mmp1a drives in vivo tumorigenesis. PMID: 23708660
    3. Matrix metalloproteinase Mmp-1a is not required for growth and fertility in mice and has a role in lung cancer progression by modulating inflammatory responses PMID: 23548910
  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 数据库链接：

    KEGG: mmu:83995

    STRING: 10090.ENSMUSP00000034492

    UniGene: Mm.156952