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  4. Recombinant Mouse Kallikrein-7 (Klk7)

Recombinant Mouse Kallikrein-7 (Klk7)

  • 中文名称：
    小鼠Klk7重组蛋白
  • 货号：
    CSB-YP835562MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Klk7重组蛋白
  • 货号：
    CSB-EP835562MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Klk7重组蛋白
  • 货号：
    CSB-EP835562MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Klk7重组蛋白
  • 货号：
    CSB-BP835562MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Klk7重组蛋白
  • 货号：
    CSB-MP835562MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Klk7; Prss6; ScceKallikrein-7; EC 3.4.21.117; Serine protease 6; Stratum corneum chymotryptic enzyme; Thymopsin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-249
  • 氨基酸序列
    IIDGY KCKEGSHPWQ VALLKGNQLH CGGVLVDKYW VLTAAHCKMG QYQVQLGSDK IGDQSAQKIK ATKSFRHPGY STKTHVNDIM LVRLDEPVKM SSKVEAVQLP EHCEPPGTSC TVSGWGTTTS PDVTFPSDLM CSDVKLISSR ECKKVYKDLL GKTMLCAGIP DSKTNTCNGD SGGPLVCNDT LQGLVSWGTY PCGQPNDPGV YTQVCKYKRW VMETMKTHR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
  • 基因功能参考文献：
    1. A previously unrecognized role of KLK7 in adipose tissue with effects on whole body energy expenditure and insulin sensitivity. PMID: 28932870
    2. Ablation of KLK7 is not sufficient to rescue the lethal effect of LEKTI-deficiency. Double deficiency of both KLK7 and KLK5 completely rescues Netherton Syndrome-like phenotype. PMID: 28095415
    3. Higher hK7 expression is associated with cervical adenocarcinomas PMID: 15492784
    4. Prolonged Klk7 neutralization provokes profound abnormalities in Klk7 function, due to pH-induced high serine protease activity that degrades lipid processing enzymes and corneodesmosomes proteins. PMID: 16117792
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family, Kallikrein subfamily
  • 组织特异性：
    Expressed in skin and, at lower levels, in lung, kidney, brain, heart and spleen. In skin, expressed in high suprabasal keratinocytes and in the luminal parts of hair follicles. Not detected in liver and skeletal muscle.
  • 数据库链接：

    KEGG: mmu:23993

    STRING: 10090.ENSMUSP00000032955

    UniGene: Mm.251227