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  4. Recombinant Mouse Keratocan (Kera)

Recombinant Mouse Keratocan (Kera)

  • 中文名称：
    小鼠Kera重组蛋白
  • 货号：
    CSB-YP012149MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Kera重组蛋白
  • 货号：
    CSB-EP012149MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Kera重组蛋白
  • 货号：
    CSB-EP012149MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Kera重组蛋白
  • 货号：
    CSB-BP012149MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Kera重组蛋白
  • 货号：
    CSB-MP012149MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kera
  • Uniprot No.：
  • 别名：
    Kera; KtcnKeratocan; KTN; Keratan sulfate proteoglycan keratocan
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    21-351
  • 氨基酸序列
    QSVRQAYEIQ DPEDWDVHDD FYCPRECFCP PSFPTALYCE NRGLTEIPPI PSRIWYLYLE NNLIESIPEK PFENATQLRW INLNKNKITN YGIEKGALSQ LKKLLFLFLE DNELEEVPSP LPRSLEQLQL ARNKVSRIPQ GTFSNLENLT LLDLQHNKLL DNAFQRDTFK GLKNLMQLNM AKNALRNMPP RLPANTMQLF LDNNSIEGIP ENYFNVIPKV AFLRLNHNKL SDAGLPSRGF DVSSILDLQL SYNQLTNFPR INANLQHLHL DHNKIKNVNM SVICPTTLRA EQDAFIHGPQ LSYLRLDGNE IKPPIPIDLV ACFKLLQAFI I
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.
  • 基因功能参考文献：
    1. rare variant in KERA was identified in a large kindred with premature atherosclerosis PMID: 24879339
    2. our results demonstrate the expression of keratocan by osteoblast lineage cells and its ability to modulate osteoblast function. PMID: 21405980
    3. Keratocan plays a unique role in maintaining the appropriate corneal shape to ensure normal vision PMID: 12665512
    4. Keratocan-deficient mice have corneal collagen fibrils with significantly larger diameters than those in wild-type mice, and increased centre-to-centre spacing of the fibrils. PMID: 14667839
    5. lumican has a novel regulatory role in keratocan expression at the transcriptional level PMID: 15849191
    6. lumican and keratocan core proteins bind the CXC chemokine KC during a corneal inflammatory response, indicating that corneal KSPGs mediate neutrophil recruitment to the cornea by regulating chemokine gradient formation. PMID: 17911102

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily
  • 组织特异性：
    Selectively expressed in cornea of adult where it is detected in keratocytes but not in scleral cells. In embryo, first detected in periocular mesenchymal cells migrating toward developing cornea on E13.5; expression gradually restricted to corneal stroma
  • 数据库链接：

    KEGG: mmu:16545

    STRING: 10090.ENSMUSP00000100923

    UniGene: Mm.6228