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  4. Recombinant Mouse Killer cell lectin-like receptor subfamily B member 1B allele B (Klrb1b), partial

Recombinant Mouse Killer cell lectin-like receptor subfamily B member 1B allele B (Klrb1b), partial

  • 中文名称：
    小鼠Klrb1b重组蛋白
  • 货号：
    CSB-YP860794MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Klrb1b重组蛋白
  • 货号：
    CSB-EP860794MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Klrb1b重组蛋白
  • 货号：
    CSB-EP860794MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Klrb1b重组蛋白
  • 货号：
    CSB-BP860794MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Klrb1b重组蛋白
  • 货号：
    CSB-MP860794MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Klrb1b
  • Uniprot No.：
  • 别名：
    Klrb1b; Klrb1d; Ly55d; Nkrp1b; Nkrp1dKiller cell lectin-like receptor subfamily B member 1B allele B; CD161 antigen-like family member B; Inhibitory receptor NKR-P1B; Lymphocyte antigen 55d; Ly-55d; NKR-P1D; Natural killer cell surface protein NKR-P1B allele B6; CD antigen CD161b
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent 'missing-self' recognition of allografts, tumor cells and virus-infected cells.
  • 基因功能参考文献：
    1. findings show that NKR-P1B negatively regulates the NK cell-mediated immune response during murine cytomegalovirus Infection PMID: 27511735
    2. The intention is to provide the basis for conducting structural studies of the inhibitory Nkrp1b protein PMID: 26447598
    3. Data suggest that killer cell lectin-like receptors NKR-P1B:Clr-b (Klrb1:Clec2d) interactions may provide a model for human hematopoietic cell transplants. PMID: 25681346
    4. cloning and characterization of a cognate ligand, Ocil, for the inhibitory NK receptors (NKR)-P1B and NKR-P1D (CD161b/d) PMID: 14990792
    5. Engagement of NKR-P1C stimulates cytotoxicity of target cells, Ca2+ flux, phosphatidylinositol turnover, kinase activity, and cytokine production. In contrast, NKR-P1B engagement inhibits NK cell cytotoxicity. PMID: 15814704
    6. Allelic divergence of Nkrp1b/c gene products helps explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse natural killer cells. PMID: 16751398

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Expressed in NK cells and a subset of T-cells.
  • 数据库链接：

    KEGG: mmu:80782

    STRING: 10090.ENSMUSP00000032472

    UniGene: Mm.480764