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  4. Recombinant Mouse LIM and cysteine-rich domains protein 1 (Lmcd1)

Recombinant Mouse LIM and cysteine-rich domains protein 1 (Lmcd1)

  • 中文名称：
    小鼠Lmcd1重组蛋白
  • 货号：
    CSB-YP855344MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lmcd1重组蛋白
  • 货号：
    CSB-EP855344MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lmcd1重组蛋白
  • 货号：
    CSB-EP855344MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lmcd1重组蛋白
  • 货号：
    CSB-BP855344MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lmcd1重组蛋白
  • 货号：
    CSB-MP855344MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lmcd1
  • Uniprot No.：
  • 别名：
    Lmcd1; LIM and cysteine-rich domains protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-365
  • 氨基酸序列
    MAKVAKDLNP GVQKMSLGQQ QSARGVACLR CKGMCSGFEP HSWRKICKSC KCSQEEHCLS SDLDDDRKIG RLLMDSKYAT LTARVKGGDG IRIYKRNRMI MTNPIATGKD PTFDTITYEW APPGVTQKLG LQYMELIPKE RQPVTGTEGA LYRRRQLMHQ LPIYDQDPSR CRGLVENELK AMEEFVKHYK SEALGVGEVA LPGQGGLPKE ENKTQEKPEG TETTAPTTNG SLGDPSKEVE YVCELCKGAA PVDSPVVYAD RAGYSKQWHP TCFQCIKCSE PLVDLIYFWK DGAPWCGRHY CESVRPRCSG CDEIIFSEDY QRVEDLAWHR KHFICEGCEQ LLSGRAYIVT KGQLLCPTCS KSKRS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
  • 基因功能参考文献：
    1. Study show that the novel LIM protein Lmcd1/Dyxin is both sufficient and necessary for cardiomyocyte hypertrophy. PMID: 20600098
    2. Expression of LMCD1/dyxin is remarkably similar to that of GATA6, with high-level expression observed in distal airway epithelium of the lung, vascular smooth muscle, and myocardium. PMID: 16199866
  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=May shuttle between the cytoplasm and the nucleus.
  • 组织特异性：
    Expressed in distal airway epithelium of the lung, vascular smooth muscle, and myocardium.
  • 数据库链接：

    KEGG: mmu:30937

    STRING: 10090.ENSMUSP00000032376

    UniGene: Mm.234441