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  4. Recombinant Mouse La-related protein 7 (Larp7)

Recombinant Mouse La-related protein 7 (Larp7)

  • 货号：
    CSB-YP012756MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP012756MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP012756MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP012756MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP012756MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Larp7; D3Wsu161e; La-related protein 7; La ribonucleoprotein domain family member 7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-570
  • 氨基酸序列
    METENQKTME ESTKRKEEKK KRSRVKQVLA DIAKQVDFWF GDANLHKDKF LREQIEKSRD GYVDISLLVS FNKMKKLTTD GKLIARALKS SSVVELDLEG TRIRRKKPLG ERPKDEEERT VYVELLPKNV THSWIERVFG KCGNVVYISI PHYKSTGDPK GFAFVEFETK EQAAKAIEFL NNPPEEAPRK PGIFPKTVKN KPIPSLRVAE EKKKKKKKKG RIKKEESVQA KESAVDSSSS GVCKATKRPR TASEGSEAET PEAPKQPAKK KKKRDKVEAS SLPEARAGKR ERCSAEDEDC LPPRPKAKKR AQKDGVGQAA SEVSKESRDL EFCSTEEEKE TDRKGDSLSK VKRKHKKKHK ERHKMGEEVI PLRVLSKTEW MDLKKEYLAL QKASMASLKK TISQIKLESE METDCKAPTA GSGQECSTQE KVSAQGPQFV TGVIVKIVSG EPLPGRKQVK DILATISEVV YIDLLEGDTE CHARFKTPED AQAVMNAQTE IRKKHSWNLE VLSGDHEQRY WQKILVDRQA KLNQPREKKR GTEKLITKAE KIRLAKTQQA SQHIRFSEYD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif. U6 snRNA processing is required for spermatogenesis.
  • 基因功能参考文献：
    1. LARP7 interacts with TUT1 nucleotidyl transferase to regulate Lin28 expression. PMID: 24768001
  • 亚细胞定位：
    Nucleus, nucleoplasm.
  • 数据库链接：

    KEGG: mmu:28036

    STRING: 10090.ENSMUSP00000029588

    UniGene: Mm.291032