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  4. Recombinant Mouse Leucine-rich repeats and immunoglobulin-like domains protein 1 (Lrig1), partial

Recombinant Mouse Leucine-rich repeats and immunoglobulin-like domains protein 1 (Lrig1), partial

  • 中文名称：
    小鼠Lrig1重组蛋白
  • 货号：
    CSB-YP013084MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lrig1重组蛋白
  • 货号：
    CSB-EP013084MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lrig1重组蛋白
  • 货号：
    CSB-EP013084MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lrig1重组蛋白
  • 货号：
    CSB-BP013084MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lrig1重组蛋白
  • 货号：
    CSB-MP013084MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lrig1
  • Uniprot No.：
  • 别名：
    Lrig1; Leucine-rich repeats and immunoglobulin-like domains protein 1; LIG-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
  • 基因功能参考文献：
    1. Lrig1 marks gastric corpus epithelial progenitor cells capable of repopulating the damaged oxyntic mucosa by differentiating into normal gastric lineage cells in mouse stomach. PMID: 28814482
    2. findings reveal a novel and essential role of Lrig1 in regulating morphogenic events that shape the hippocampal circuits and establish that the assembly of TrkB with Lrig1 represents a key mechanism for understanding how specific neuronal populations expand the repertoire of responses to BDNF during brain development PMID: 26935556
    3. LRIG1 role in the atrophic epidermis PMID: 28099467
    4. LRIG1+ cells were found to re-populate the neo-epidermis on day 14, suggesting an important homeostatic role of LRIG1 in skin PMID: 26753643
    5. a subset of human duodenal tumors exhibited features of LRIG1(-/-) adenomas, including loss of LRIG1, gastric metaplasia (MUCIN5AC and MUCIN6), and increased amphiregulin and Egfr activity. PMID: 25794708
    6. LRIG1 regulates the postnatal development of ICC-DMP and ICC-SMP from smooth muscle progenitors in mice. PMID: 25921371
    7. Loss of one Apc allele in Lrig1(+) cells results in inducible stem cell-driven model that recapitulates features of familial adenomatous polyposis. PMID: 24833705
    8. At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia. PMID: 24086156
    9. LRIG1 orchestrates corneal-tissue transparency and cell fate during repair via STAT3. PMID: 24316976
    10. A review summarizes the data that LRIG1 is a ERBB negative regulator and tumour suppressor. PMID: 23558895
    11. LRIG1 Loss of heterozygosity (LOH) is frequent across cancers and its loss is an early event in the development of human squamous carcinomas. PMID: 23208928
    12. The Lrig1, a negative-feedback regulator of the ErbB receptor family, is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signalling. PMID: 22388892
    13. Study demonstrates that Lrig1 null mice develop duodenal adenomas, providing in vivo evidence that the ErbB negative regulator Lrig1 functions as a tumor suppressor. PMID: 22464327
    14. Data show a dynamic expression pattern for diverse hair follicle (HF) stem cell markers Sox9 and Lrig1. PMID: 22227295
    15. LIG-1 inversely correlated with proliferative ability of epidermal keratinocytes. PMID: 12067728
    16. LRIG1-mediated receptor ubiquitination and degradation may contribute to the suppression of ErbB receptor function PMID: 15345710
    17. Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer. PMID: 18922900
    18. Our results suggest that Lrig1-positive cells constitute a previously unidentified reservoir of adult mouse interfollicular epidermal stem cells. PMID: 19427292

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Detected in brain (at protein level). Predominantly expressed in the brain, restricted to a small subset of glial cells, such as Bergmann glial cells of the cerebellum and glial cells in the nerve fiber layer of the olfactory bulb. Expressed also in the s
  • 数据库链接：

    KEGG: mmu:16206

    STRING: 10090.ENSMUSP00000032105

    UniGene: Mm.245210