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  4. Recombinant Mouse Low affinity cationic amino acid transporter 2 (Slc7a2), partial

Recombinant Mouse Low affinity cationic amino acid transporter 2 (Slc7a2), partial

  • 中文名称：
    小鼠Slc7a2重组蛋白
  • 货号：
    CSB-YP021714MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc7a2重组蛋白
  • 货号：
    CSB-EP021714MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc7a2重组蛋白
  • 货号：
    CSB-EP021714MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc7a2重组蛋白
  • 货号：
    CSB-BP021714MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc7a2重组蛋白
  • 货号：
    CSB-MP021714MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc7a2
  • Uniprot No.：
  • 别名：
    Slc7a2; Atrc2; TeaCationic amino acid transporter 2; CAT-2; CAT2; 20.5; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2; T-cell early activation protein; TEA
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Isoform 1 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Isoform 2 also functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), but it has much higher affinity for arginine than isoform 1. May play a role in classical or alternative activation of macrophages via its role in arginine transport.
  • 基因功能参考文献：
    1. In the absence of CAT2, Myeloid-derived suppressor cells display diminished capacity for controlling T cell immunity in prostate inflammation and cancer models, where the loss of CAT2 results in enhanced antitumor activity. PMID: 26491198
    2. demonstration of how most nuclear-retained CTN-RNAs stabilize at the periphery of paraspeckles, how CTN-RNA regulates its protein-coding partner, and how the mCAT2 gene can maintain a stable expression PMID: 25619276
    3. cationic transporter CAT2 plays an important role in controlling inflammation and IL-17 activation in an injury model of colitis PMID: 23703655
    4. These results demonstrate that the availability of arginine, mediated by Slc7a2, controls critical aspects of macrophage activation and reveal a factor for susceptibility to Leishmania infection. PMID: 23460752
    5. CAT-2A and CAT-1 L-arginine transporters are increased in cardiomyocytes from Duchenne muscular dystrophy mice. PMID: 23009292
    6. CAT2 is an important regulator of the immune response during H. pylori infection. PMID: 22194986
    7. Uptake of L-Arg, and its metabolism by Arg1 to L-Orn and conversion to L-Pro by OAT is essential for colonic epithelial wound repair. PMID: 22361732
    8. Results identify CAT2 as a regulator of fibrotic responses in the lung. PMID: 20576117
    9. IL-10 attenuated the LPS-induced upregulation of CAT-2 mRNA in macrophage cells. Results suggest that transcriptional control of CAT-2 by IL-10 regulates iNOS activity. PMID: 11829538
    10. The cationic amino acid transporter 2B may regulate supply of L-arginine to iNOS. PMID: 15631944
    11. We conclude that BMM present mainly y(+)L activity and that, in response to GM-CSF, l-arginine transport augments through CAT2, thereby increasing the availability of this amino acid to the cell. PMID: 16371438
    12. Increased L-arginine transport mediated by both T helper cell (Th)1-type and Th2-type endogenous activators is strongly regulated by Slc7a2/CAT2 expression, which could limit the function of macrophages. PMID: 16670299
    13. SLC7A2 mediates the increase in arginine transport in mouse macrophages during activition but not during proliferation. PMID: 16703566
    14. These data suggest that CAT2 regulates anti-inflammatory processes in the lungs via regulation of dendritic cell activation and subsequent T cell responses. PMID: 17003120
    15. CAT-2 exerts control over airway smooth muscle force development through a spermine-dependent pathway that directly correlates with the expression level of PIP-5K-gamma in the lung. PMID: 17644755
    16. By controlling NOS2 and arginase activity, CAT2 functions as a potent regulator of immunity. PMID: 18369473

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2.A.3.3) family
  • 组织特异性：
    Detected in liver (at protein level). Highest expression in liver and T-cells. Also expressed in brain and lung.
  • 数据库链接：

    KEGG: mmu:11988

    STRING: 10090.ENSMUSP00000096414

    UniGene: Mm.4676