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  4. Recombinant Mouse Lymphocyte antigen 6C1 (Ly6c1)

Recombinant Mouse Lymphocyte antigen 6C1 (Ly6c1)

In Stock
  • 中文名称：
    小鼠Ly6c1重组蛋白
  • 货号：
    CSB-YP317813MOa4
  • 规格：
    ￥2616
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Ly6c1
  • Uniprot No.：
  • 别名：
    Ly6c1; Lymphocyte antigen 6C1; Ly-6C1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    Yeast
  • 分子量：
    25.1kDa
  • 表达区域：
    27-109aa
  • 氨基酸序列
    LQCYECYGVPIETSCPAVTCRASDGFCIAQNIELIEDSQRRKLKTRQCLSFCPAGVPIRDPNIRERTSCCSEDLCNAAVPTAG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMOSTAR-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Splenic Ly6C(hi) monocytes contribute to adverse late post-ischemic left ventricular remodeling in heme oxygenase-1 deficient mice. PMID: 28534119
    2. CX3CL1 is upregulated in both human and murine tumors following VEGF signaling blockade, resulting in recruitment of CX3CR1+Ly6Clo monocytes into the tumor PMID: 28691930
    3. surface expression on Ly6C(high) monocytes changes in a time-of-day-dependent manner, which crucially affects cardiac monocyte recruitment after an acute ischemic event. PMID: 28663258
    4. monocyte differentiation occurred through de novo enhancer establishment and activation of pre-established (poised) enhancers. Generation of Ly6C(-) monocytes involved induction of the transcription factor C/EBPbeta and C/EBPbeta-deficient mice lacked Ly6C(-) monocytes. PMID: 28514690
    5. Ly6C, 4-1BB, and KLRG1 have roles in the activation of lamina propria lymphocytes in the small intestine in a mouse model of Crohn's disease PMID: 28011265
    6. The adapter Mal (encoded by TIRAP) has appeared crucial for the cytokine production by Ly6C(lo) but not by Ly6C(hi) monocytes. The protein Mal was necessary to induce cytokine synthesis by Ly6C(lo) monocytes after triggering TLR2 or TLR9. PMID: 27646001
    7. Data show that Ly6C(high) monocyte subset after middle cerebral artery occlusion/reperfusion (MCAO/R) peaked on day 2 after the operation and was correlated with cerebral infarct size. PMID: 26927544
    8. Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection. PMID: 25473946
    9. Monocytes expressing Ly-6C orchestrate both inflammatory and reparative phases during myocardial infarction. PMID: 24625784
    10. MPYS-deficient Ly6C(hi) monocytes are intrinsically defective in migration to the liver, but not the spleen. PMID: 23378430
    11. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. PMID: 23100531
    12. Identify for the involvement of inflammatory Ly-6C(hi) monocytes in the pathogenesis of transplant arteriosclerosis, particularly in conditions of hyperlipidemia. PMID: 22704806
    13. decreased Ly6C and T-bet (Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection PMID: 22018471
    14. TNF-alpha-dependent regulation of acute pancreatitis severity by Ly-6C(hi) monocytes in mice. PMID: 21343291
    15. Ly6C(high-expressing) and Ly6C(low-expressing) bone marrow (BM)-derived monocytes have different fates, demonstrating that BM may be a reservoir of preinflammatory monocytes for rapid deployment as inflammatory dendritic cells during virus infection. PMID: 21248254
    16. in vitro and in vivo differentiation of naive CD8(+) T cells into central (Tcm) but not effector (Tem) memory T cells enhances Ly6C expression, and its crosslinking induces strong LFA-1 clustering on Tcm PMID: 21308682
    17. The tumor-monocyte pool almost exclusively consisted of Ly6C(hi)CX(3)CR1(low) monocytes, which continuously seeded tumors and renewed all nonproliferating tumor associated macrophages subsets. PMID: 20570887
    18. Th1 but not Th2 cytokine environments transiently induce the expression of Ly-6C on B cells. There are differences in the regulation of Ly-6C expression in Ly6.1 and Ly6.2 strains. PMID: 12184918
    19. Ly6C when cross-linked is able to regulate endothelial adhesion of CD8 T cells via activation of LFA-1 in a manner that involves Ly6C down-regulation on the cell surface. PMID: 12538687
    20. During systemic listeria infection, a subset of Ly-6C-expressing monocytes transports L. monocytogenes into the brain and establishes its role of bacterial spreading in vivo. PMID: 15034057
    21. plasmacytoid dendritic cells can only be derived from the CD31(high)/Ly6C(-) subset, the subset that reportedly contains the highest frequency of early and late cobblestone area forming cells PMID: 17084826
    22. Ly-6C(hi) monocytes represent a newly recognized component of the inflammatory response in experimental atherosclerosis. PMID: 17200719
    23. In resting lung, Ly-6C(high)CCR2(high) monocytes repopulate CD103-positive dendritic cells (DCs) using a CCR2-dependent mechanism, and these DCs preferentially retain residual CCR2 in the lung. PMID: 18292524
    24. DeltaactA-infected IFN-gamma-/- mice had no brain influx of Ly-6Chigh monocytes despite normal monocyte trafficking from bone marrow to blood and spleen PMID: 18566419
    25. Data suggest that CCL2-dependent, Ly6C+ inflammatory monocyte migration is critical for increases in microglia during West Nile Virus infection and may also play a pathogenic role during WNV encephalitis. PMID: 18779347
    26. Granulocyte-macrophage colony-stimulating factor-driven release of Ly6C(hi) precursors from the bone marrow prevents exhaustion of central nervous system myeloid populations during relapsing or chronic autoimmune demyelination. PMID: 19196868
    27. Ly6C(low-expressing) mature monocytes can promote tolerance to self antigen contained in apoptotic cells through a programmed death ligand (PDL-1)-dependent mechanism. PMID: 19234172
    28. Gr-1 Ab induces signals leading to myelopoiesis and affects myeloid-derived suppressor cell activity, suggesting functional roles for Ly-6C/G molecules in macrophage differentiation and neutrophil apoptosis. PMID: 19830733
    29. Ly6C is a marker of macrophage subsets and support a model of selective recruitment of Ly6C(high) bone marrow monocytes to the kidney that differentiate into three populations of kidney macrophages, including a profibrotic Ly6C(low) population. PMID: 19864592

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 数据库链接：

    KEGG: mmu:17067

    STRING: 10090.ENSMUSP00000066954

    UniGene: Mm.1583