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  4. Recombinant Mouse Macrophage asialoglycoprotein-binding protein 1 (Mgl1), partial

Recombinant Mouse Macrophage asialoglycoprotein-binding protein 1 (Mgl1), partial

  • 货号：
    CSB-YP342996MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP342996MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP342996MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP342996MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP342996MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Clec10a
  • Uniprot No.：
  • 别名：
    Clec10a; Mgl; Mgl1C-type lectin domain family 10 member A; MMGL; Macrophage asialoglycoprotein-binding protein 1; M-ASGP-BP-1; Macrophage galactose/N-acetylgalactosamine-specific lectin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Recognizes terminal galactose and N-acetylgalactosamine units. May participate in the interaction between tumoricidal macrophages and tumor cells. Plays a role in the recruitment of inflammatory monocytes to adipose tissue in diet-induced obesity.
  • 基因功能参考文献：
    1. Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia PMID: 26912318
    2. Mgl1-deficient mice displayed accelerated colonic propulsion and were hypersensitive to mu receptor-mediated inhibition of colonic motility. PMID: 26075589
    3. MGL1 is involved in T. crassiceps recognition and subsequent innate immune activation and resistance. PMID: 25664320
    4. The MGL1 functions as an attachment and entry receptor for influenza A virus. PMID: 24257596
    5. Syk was involved in the CLR-mediated activation of mast cells by BP PMID: 23794711
    6. Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion. PMID: 21773674
    7. The s conclude that lectin-mediated interactions of influenza virus with the MMR or the MGL are required for the endocytic uptake of the virus into macrophages. PMID: 20106926
    8. mMGL1 preferentially binds Lewis X-conjugated soluble polyacrylamides PMID: 12016228
    9. Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins. PMID: 12077344
    10. sialoadhesin acts as an endogenous counter-receptor for MGL1 PMID: 15364954
    11. The mMGL1 protein is induced in diverse populations of aaMF, including peritoneal macrophages elicited during infection with the protozoan Trypanosoma brucei brucei or the Helminth Taenia crassiceps and alveolar macrophages elicited. PMID: 15591125
    12. MGL1 expressed on a specific subpopulation of macrophages that secrete IL-1alpha was proposed to regulate specific cellular interactions crucial to granulation tissue formation PMID: 15784728
    13. MGL1/CD301a is involved in the clearance of apoptotic cells PMID: 16096344
    14. analysis of protein-protein interactions in the Mgl-1 oncoprotein PMID: 16969496
    15. MGL1 mutants of Ala89Arg and Ala89Arg/Pro115Arg showed beta-GalNAc bindings. PMID: 18053814
    16. Carbohydrate binding mechanism of the macrophage galactose-type C-type lectin 1 revealed by saturation transfer experiments.( PMID: 18790731
    17. MGL1/CD301a plays a protective role against colitis PMID: 19095961
    18. MGL1 as a novel regulator of inflammatory monocyte trafficking to adipose tissue in response to diet-induced obesity. PMID: 19995956

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Detected in lymph node in the subcapsular sinus, interfollicular regions, T and B-cell boundary and in the areas surrounding high endothelial venules (at protein level). Expressed on the surface of activated macrophages. Expressed in heart, lung, testis,
  • 数据库链接：

    KEGG: mmu:17312

    STRING: 10090.ENSMUSP00000000327

    UniGene: Mm.252405