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  4. Recombinant Mouse Mannose-binding protein A (Mbl1)

Recombinant Mouse Mannose-binding protein A (Mbl1)

  • 中文名称：
    小鼠Mbl1重组蛋白
  • 货号：
    CSB-YP327925MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mbl1重组蛋白
  • 货号：
    CSB-EP327925MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mbl1重组蛋白
  • 货号：
    CSB-EP327925MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mbl1重组蛋白
  • 货号：
    CSB-BP327925MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mbl1重组蛋白
  • 货号：
    CSB-MP327925MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mbl1
  • Uniprot No.：
  • 别名：
    Mbl1Mannose-binding protein A; MBP-A; Mannan-binding protein; Ra-reactive factor polysaccharide-binding component p28B; RaRF p28B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-239
  • 氨基酸序列
    SSG SQTCEDTLKT CSVIACGRDG RDGPKGEKGE PGQGLRGLQG PPGKLGPPGS VGSPGSPGPK GQKGDHGDNR AIEEKLANME AEIRILKSKL QLTNKLHAFS MGKKSGKKLF VTNHEKMPFS KVKSLCTELQ GTVAIPRNAE ENKAIQEVAT GIAFLGITDE ATEGQFMYVT GGRLTYSNWK KDEPNNHGSG EDCVIILDNG LWNDISCQAS FKAVCEFPA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages.
  • 基因功能参考文献：
    1. Our study provides comprehensive information regarding spatial and temporal expression of collectins (SP-A, SP-D and MBL-A) and their cellular sources in murine testis. Positive regulation by testosterone and alteration in their level upon LPS challenge are clues relevant to suggest their involvement in testicular immune privilege PMID: 27262512
    2. this study shows that MBL-A expression is induced in the gut in response to Candida albicans sensing and is required for intestinal homeostasis and host defense against Candida albicans PMID: 26442658
    3. Targeted deletion of Mbl1/2 causes differential levels of inflammation-related gene sets at baseline and after exposure to ozone and significantly reduces pulmonary inflammation, thus indicating an important innate immunomodulatory role of the Mbl1/2 genes. PMID: 27106289
    4. Data indicate that lysyl hydroxylase 3 is essential for the glucosyltion of mannan-binding lectin MBL-A. PMID: 25419660
    5. MBL deficiency in knockout mice reduces deposition of fibrin(ogen) in blood vessels of ischemic tissue and emphasizes a role for MBL in local thrombus formation during acute ischemia/reperfusion. PMID: 24676774
    6. Data indicate that no change of mannan-binding lectin MBL-A during the study, however, mannan-binding lectin MBL-C concentration increased in median by 3.6-fold (2.9; 4.5-fold) during the study in the diabetic group. PMID: 23350935
    7. Our data show an important role for MBL in the pathogenesis of brain ischemic injury and provide a strong support to the concept that MBL inhibition may be a relevant therapeutic target. PMID: 22879370
    8. Mannan-binding lectin has a role in diabetic kidney disease PMID: 22645604
    9. the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to ischemia/reperfusion injury on kidney transplantation and hemorrhagic shock PMID: 21835783
    10. MBL deficiency plays a potentially protective role in neutrophil-mediated cerebral injury after ischemia reperfusion. PMID: 21208161
    11. Data show that genetically defined MBL-deficiency is associated with a better outcome after acute stroke. PMID: 20140243
    12. Recombinant mouse ficolin A, mannose-binding lectin-A, and mannose-binding lectin-C bound to fibrinogen in a dose-dependent manner. The lectin pathway, through mannose-binding lectins, synchronized with blood coagulation. PMID: 20375621
    13. MBL-A null mice had enhanced survival in a septic peritonitis model compared to wild-type mice PMID: 12270724
    14. MBL-A has been detected in liver, lung, kidney, and testis but not in the small intestine. PMID: 12471128
    15. MBL-A is not required for mouse survival following exposure to A. fumigatus conidia; this isoform contributes to the development and maintenance of airway hyperresponsiveness but not chronic airway remodeling during chronic fungal asthma. PMID: 14761934
    16. the MBL-dependent pathway of complement activation is a key regulator of myocardial reperfusion ischemic injury PMID: 15972690
    17. There is an MBL-dependent mechanism of host resistance against S. aureus infection. PMID: 16299314
    18. MBL has a pivotal role in the development of diabetic kidney disea PMID: 17473913
    19. Toll-like receptors 2 and 6 signaling from the phagosome is enhanced by mannose-binding lectin PMID: 18180310
    20. MBL deficiency increases susceptibility to controlled cortical impact through C3-independent mechanisms PMID: 18183030
    21. MBL-A is not a necessary component for immunity to either T. muris or S. mansoni helminths, however, MBL-A appears to be necessary for the development of specific IgM responses to nematode antigens. PMID: 19149778
    22. MBL is abundantly present and locally produced during early atherogenesis PMID: 19380618
    23. Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin-A and -C. PMID: 19749170

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Detected in liver and blood serum (at protein level). Detected in liver.
  • 数据库链接：

    KEGG: mmu:17194

    STRING: 10090.ENSMUSP00000048765

    UniGene: Mm.281805