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  4. Recombinant Mouse Maspardin (Spg21)

Recombinant Mouse Maspardin (Spg21)

  • 货号：
    CSB-YP880401MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP880401MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP880401MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP880401MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP880401MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Spg21; Maspardin; Acid cluster protein 33; Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-308
  • 氨基酸序列
    MGEIKVSPDY NWFRSTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP PVSGTADVFF QQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE YTHKSPRVHS LILCNAFSDT SIFNQTWTAN SFWLMPAFML KKIVLGNFSS GPVDPMMADA IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDVFDQSAL STEAKEEMYK LYPNARRAHL KTGGNFPYLC RSAEVNLYVQ IHLLQFHGTK YAAIDPSVVS AEELEVQKGR LGLSQEEP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role as a negative regulatory factor in CD4-dependent T-cell activation.
  • 基因功能参考文献：
    1. Study showed that the loss of maspardin attenuates the growth, maturation, and axonal branching of cortical neurons to promote progressive neuronal dysfunction; impairment of sensory motor neurons in SPG21-/- mice; and that SPG21-/- cortical neurons failed to respond to EGF-induced growth and maturation, which is confirmed by the attenuated expression of a subset of EGFR target genes PMID: 26978163
    2. Mast syndrome gene SPG21 in mice has a role in hind limb function and axon branching in cultured cortical neurons PMID: 20661613
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    AB hydrolase superfamily
  • 组织特异性：
    Expressed in cell lines FT.1 and in a L cell fibroblast derivative (at protein level).
  • 数据库链接：

    KEGG: mmu:27965

    STRING: 10090.ENSMUSP00000034955

    UniGene: Mm.272475