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  4. Recombinant Mouse Melanoma-associated antigen D1 (Maged1)

Recombinant Mouse Melanoma-associated antigen D1 (Maged1)

  • 中文名称：
    小鼠Maged1重组蛋白
  • 货号：
    CSB-YP874126MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Maged1重组蛋白
  • 货号：
    CSB-EP874126MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Maged1重组蛋白
  • 货号：
    CSB-EP874126MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Maged1重组蛋白
  • 货号：
    CSB-BP874126MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Maged1重组蛋白
  • 货号：
    CSB-MP874126MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Maged1; Nrage; Melanoma-associated antigen D1; Dlxin-1; MAGE-D1 antigen; Neurotrophin receptor-interacting MAGE homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-775
  • 氨基酸序列
    MAQKPDGGAG LRGFQAEASV EDSALLVQTL MEAIQISEAP PTSQATAAAS GPNASPQSSQ PPTANEKADT EVSAAAARPK TGFKAQNATT KGPNDYSQAR NAKEMPKNQS KAAFKSQNGT PKGPHAASDF SQAAPTGKSA KKSEMAFKGQ NSTKAGPGTT YNFPQSPSAN EMTNNQPKTA KAWNDTTKVP GADAQTQNVN QAKMADVGTS AGISEADGAA AQTSADGSQT QNVESRTIIR GKRTRKVNNL NVEENNSGDQ RRASLASGNW RSAPVPVTTQ QNPPGAPPNV VWQTPLAWQN PSGWQNQTAR QTPPAARQSP PARQTPSAWQ NPVAWQNPVI WPNPVIWQNP VIWPNPIVWP GPIVWPNPMA WQSTPGWQSP PSWQAPPSWQ SPQDWQGPPD WQVPPDWSMP PDWSFPSDWP FPPDWIPADW PIPPDWQNLR PSPNLRSSSN SRASQNQGPP QPRDVALLQE RANKLVKYLM LKDYTKVPIK RSEMLRDIIR EYTDVYPEII ERACFVLEKK FGIQLKEIDK EEHLYILIST PESLAGILGT TKDTPKLGLL LVILGIIFMN GNRATEAVLW EALRKMGLRP GVRHPLLGDL RKLLTYEFVK QKYLDYRRVP NSNPPEYEFL WGLRSYHETS KMKVLRFIAE VQKRDPRDWT AQFMEAADEA LDALDAAAAE AEARAEARNR MGIGDEAVSG PWSWDDIEFE LLTWDEEGDF GDPWSRIPFT FWARYHQNAR SRFPQAFTGP IIGPSGTATA NFAANFGAIG FFWVE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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靶点详情

  • 功能：
    Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
  • 基因功能参考文献：
    1. Both transient and stable expression of Necdin induced osteoblast-specific markers in an osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and promoter activation. PMID: 28528976
    2. MAGED1 as a novel regulator of osteoblastogenesis, osteoclastogenesis, and bone remodeling in a mouse model PMID: 26272363
    3. Maged1 deficiency prevented the interaction of Maged1 with cAMP response element-binding protein (CREB). PMID: 24700102
    4. NRAGE is a potent regulator of proliferation and odontoblastic differentiation of mouse dental pulp cells, which might be via the NF-kappaB signalling pathway. PMID: 25736627
    5. Show Ror2 expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 is a potential factor in the tumorigenesis and metastasis in a Src-dependent manner that is negatively regulated by NRAGE. PMID: 23142633
    6. We conclude that Maged1 is required for OT processing or stability. A decrease in mature OT levels in Maged1 mutants affects social interactions and possibly other behavioral processes PMID: 22865874
    7. Maged1 is involved in osteoblast proliferation and differentiation. Mice deficient in Maged1 protein had decreased bone mineral density (BMD) PMID: 23300464
    8. the present findings suggest a novel role for MAGE-D1 in depressive behaviors: modulating SERT ubiquitylation. PMID: 22457503
    9. XIAP-TAB1-TAK1 complex is dependent on NRAGE for IKK-alpha/beta phosphorylation and NF-kappaB activation. PMID: 21789165
    10. MAGED1 binds to nuclear receptor RORalpha to bring about positive and negative effects on core clock genes of Bmal1, Rev-erbalpha and E4bp4 expression through the Rev-Erbalpha/ROR responsive elements (RORE). PMID: 20300063
    11. NRAGE induces NF-kappaB activation and MIF expression in P19 cells PMID: 20100315
    12. MHD2 of NRAGE was not necessary for BMP-induced p38MAPK activation or caspase-mediated apoptosis. PMID: 19937275
    13. roles for NRAGE as a mediator of precursor apoptosis and a repressor of cell cycle progression in neural development PMID: 12204258
    14. receptor tyrosine kinase-like orphan receptor 2(Ror2) sequesters Dlxin-1 in membranous compartments, thereby affecting the transcriptional function of Mhomeobox, msh-like 2(msx2) PMID: 12754255
    15. The expression pattern of Maged1 roughly summarizes that of Maged2 and Maged3 PMID: 15162511
    16. necdin and MAGE-D1 cooperate to modulate the function of Dlx/Msx homeodomain proteins in cellular differentiation PMID: 15272023
    17. Our results suggest that interaction of cytosolic PrP and NRAGE could affect neuronal viability. PMID: 15911347
    18. NRAGE as an integral component in bone morphogenetic proteins signaling and clarify its role during neural progenitor development PMID: 16107717
    19. NRAGE plays an important role in apoptotic-signaling in vivo. PMID: 18772898
    20. NRAGE might have multiple roles during renal branching morphogenesis through association with both the BMP and GDNF signaling pathways. PMID: 19268530
    21. The netrin receptor UNC5H1 induces apoptosis through and interaction with NRAGE. PMID: 12598531

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 组织特异性：
    Ubiquitously expressed in many adult tissues, except for the spleen. Expressed in osteoblastic and chondrogenic cell lines and also during embryonic development.
  • 数据库链接：

    KEGG: mmu:94275

    STRING: 10090.ENSMUSP00000026142

    UniGene: Mm.27578