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  4. Recombinant Mouse Mesoderm posterior protein 1 (Mesp1)

Recombinant Mouse Mesoderm posterior protein 1 (Mesp1)

  • 中文名称：
    小鼠Mesp1重组蛋白
  • 货号：
    CSB-YP013709MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mesp1重组蛋白
  • 货号：
    CSB-EP013709MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mesp1重组蛋白
  • 货号：
    CSB-EP013709MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mesp1重组蛋白
  • 货号：
    CSB-BP013709MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mesp1重组蛋白
  • 货号：
    CSB-MP013709MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mesp1
  • Uniprot No.：
  • 别名：
    Mesp1Mesoderm posterior protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-243
  • 氨基酸序列
    MAQPLCEPRS ESWILSPAGR QPPMPSDGNS VCSPAWSSDP WDGAQASSPA PPCARPARRA GTPGRRGTHG SRLGSGQRQS ASEREKLRMR TLARALHELR RFLPPSVAPT GQNLTKIETL RLAIRYIGHL SAVLGLSEDN LRRQRHAVSP RGCPLCPDSD LAQSQSLGPR LSPAVCSGVS WGSPPAYPRP RVAAESWDPS FLYAETASQE RQEMEPSPSS PLFSSDMLAL LETWTPPQEW PPA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways.
  • 基因功能参考文献：
    1. This approach enabled discovery of subpopulations primed for hematopoietic or cardiac development. These studies demonstrate the heterogeneic nature of Mesp1+ mesoderm. PMID: 27131741
    2. YY1 and SP1 independently and cooperatively govern the Mesp1 expression during embryogenesis. PMID: 26384464
    3. Data indicate an embryonic stem cell-based system in which mesoderm posterior 1 protein (MESP1) drives a PDGF alpha Receptor (PDGFRA+) population with dual cardiac and skeletal muscle differentiation potential. PMID: 26771351
    4. data indicate that the myocardial layer of the heart derive from approximately 250 Mesp1-expressing cardiac progenitors born during gastrulation. PMID: 26725109
    5. MESP1, a pioneer cardiac factor, directs the appearance of mesendoderm, the intermediary of the earliest progenitors of mesoderm and endoderm organogenesis. PMID: 26205879
    6. Studies indicate that mesodermal posterior 1 (Mesp1) and mesodermal posterior 2 (Mesp2) double-knockout embryos exhibited defective development of the embryonic mesoderm. PMID: 26088191
    7. Data indicate that transcription factor Mesp1 interacts physically with cAMP-responsive element binding protein 1 (Creb1) and transcriptionally regulates Ets variant 2 (Etv2) gene expression. PMID: 25694434
    8. Embryonic heart development arises from distinct populations of unipotent and bipotent cardiac progenitors that independently express Mesp1 at different time points during their specification. PMID: 25150979
    9. This Tcf/Lef-Oct4 composite site mediated synergistic activation of the Mesp1 promoter by Oct4 and canonical Wnt signaling. PMID: 23417899
    10. Mesp1 is a context-dependent determination factor, integrating the stage of differentiation and the signaling environment to specify different lineage outcomes. PMID: 23642367
    11. These results place Eomes upstream of the Mesp1-dependent programme of cardiogenesis, and at the intersection of mesodermal and endodermal specification, depending on the levels of Activin/Nodal signalling. PMID: 22402664
    12. shRNA-based loss of Brachyury(T) causes a dramatic decrease in MesP1 expression accompanied by reduced cardiac markers in differentiating embryonic stem cells PMID: 21632880
    13. Data show that Eomes promotes formation of cardiovascular progenitors by directly activating the bHLH transcription factor gene Mesp1 upstream of the core cardiac transcriptional machinery. PMID: 21822279
    14. Mesp1 is required to promote the specification of multipotent cardiovascular progenitors (MCPs)and the expression of cardiovascular transcription factors in MCPs. PMID: 21383076
    15. approximately 20% of the ventricular cardiac conduction system within the IVS corresponds to Mesp1-nonexpressing cells PMID: 16317723
    16. Mesp1 is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo. PMID: 16996494
    17. appropriate suppression of Notch signaling by Mesp1 and Mesp2 factors is essential for stripe pattern formation leading to segment boundary formation PMID: 17306789
    18. MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling PMID: 18297060
    19. analysis of the roles of Mesp1 and Mesp2 through knockout mouse models PMID: 18328678
    20. Embryonic stem cells are used to identify a key role for Mesp1 for stem-based cardiac regeneration. PMID: 18593549
    21. Mesp1 may be capable of generating the recently identified multipotent cardiovascular progenitor from embryonic stem cells in vitro. PMID: 18593559
    22. Mesp1 acts as a key regulatory switch during cardiovascular specification, residing at the top of the hierarchy of the gene network responsible for cardiovascular cell-fate determination PMID: 18593560
    23. Report forward programming of pluripotent stem cells towards distinct cardiovascular cell types via Nkx2.5 and MesP1 pathways. PMID: 19564151

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    No expression was detected in adult tissues except the testis. Expression in the testis was regulated developmentally; expressed 2 weeks after birth, and increases, reaching the full expression level in mature testes.
  • 数据库链接：

    KEGG: mmu:17292

    STRING: 10090.ENSMUSP00000032760

    UniGene: Mm.1404