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  4. Recombinant Mouse Metastasis-associated protein MTA1 (Mta1)

Recombinant Mouse Metastasis-associated protein MTA1 (Mta1)

  • 中文名称：
    小鼠Mta1重组蛋白
  • 货号：
    CSB-YP817005MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mta1重组蛋白
  • 货号：
    CSB-EP817005MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mta1重组蛋白
  • 货号：
    CSB-EP817005MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mta1重组蛋白
  • 货号：
    CSB-BP817005MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mta1重组蛋白
  • 货号：
    CSB-MP817005MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mta1
  • Uniprot No.：
  • 别名：
    Mta1; Metastasis-associated protein MTA1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-715
  • 氨基酸序列
    MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTANGNVEA KVVCFYRRRD ISSSLIALAD KHATLSVCYR AGPGADTGEE GEVEEEVENP EMVDLPEKLK HQLRHRELFL SRQLESLPAT HIRGKCSVTL LNETESLKSY LEREDFFFYS LVYDPQQKTL LADKGEIRVG NRYQADITDL LKEGEEDGRD QSKLETKVWE AHNPLVDKQI DQFLVVARSV GTFARALDCS SSVRQPSLHM SAAAASRDIT LFHAMDTLHK NIYDISKAIS ALVPQGGPVL CRDEMEEWSA SEANLFEEAL EKYGKDFTDI QQDFLPWKSL TSIIEYYYMW KTTDRYVQQK RLKAAEAESK LKQVYIPNYN KPNPNQISAS SVKATVVNGT GTPGQSPGAG RACESCYTTQ SYQWYSWGPP NMQCRLCASC WTYWKKYGGL KMPTRLDGER PGPNRNNMSP HGIPARSSGS PKFAMKTRQA FYLHTTKLTR IARRLCREIL RPWHAARHPY MPINSAAIKA ECTARLPEAS QSPLVLKQVV RKPLEAVLRY LETHPRPPKP DPVKSSSSVL SSLTPAKSAP VINNGSPTIL GKRSYEQHNG VDGNMKKRLL MPSRGLANHG QTRHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW IDAPDDVFYM ATEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPLRP PPPAPVNDEP IVIED
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. With Tfcp2l1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation.
  • 基因功能参考文献：
    1. MTA1 participates in the formation of pulmonary capillaries via stabilization of HIF-1alpha. This finding sheds new light on the function of MTA1 in lung development. PMID: 28808223
    2. Findings illustrate how cancer cells utilize a chromatin remodeling factor to engage a core survival pathway to support its cancerous phenotypes, and reveal new facets of MTA1-SGK1 axis by a physiologic signal in cancer progression. PMID: 28504714
    3. the augmentation of endogenous MTA1 expression during neuronal ischemic injury acts additionally to an endocrinous cascade orchestrating intimate interactions between ERalpha and BCL2 pathways. PMID: 26728277
    4. Findings highlight MTA1 as a key upstream regulator of prostate tumorigenesis and cancer progression. PMID: 26943043
    5. Inhibition of MTA1 expression by in vivo siRNA treatment exacerbated the pathology of LPS-induced acute lung injury, by selectively promoting the expression of NF-kappaB-regulated inflammatory cytokines. PMID: 26891867
    6. MTA1 was regulated by HIF-1alpha in hypoxia circumstance to suppress osteoblast differentiation. PMID: 25644400
    7. MTA1 levels were increased in monosodium urate crystal-induced inflammation. PMID: 25889736
    8. The inhibition of MTA1 gene could depress the growth and metastasis of laryngeal squamous cell carcinoma in nude mice. PMID: 26359099
    9. Data suggest that nuclear metastasis-associated protein 1 (MTA1) is a good marker for cancer differentiation diagnosis and a potential target for the treatment of cancers. PMID: 24970816
    10. this study reports the potential signaling events related to up-regulation of metastasis associated protein 1 (Mta1), a master chromatin modifier, during mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cells injury. PMID: 25153068
    11. MTA1 has an important role in the maintenance of circadian rhythmicity. PMID: 24089055
    12. the MTA1/NFkappaB/FasL circuit may serve as an important defensive/repairing mechanism to help to control the germ cell quality after Sertoli cell injury. PMID: 24120950
    13. MTA1 is a major contributor to prostate tumor malignant progression. PMID: 23469203
    14. Data indicate that metastasis tumor antigen 1 (MTA1)-dependent stimulation of STAT3 transcription through action on the MTA1/STAT3/Pol II coactivator complex. PMID: 23580571
    15. The changes of the expression sites and quantity of MTA1 in the DEN-induced carcinogenesis of mouse liver indicate that MTA1 may play an important role in the whole process of liver carcinogenesis. PMID: 22863583
    16. Metastasis-associated protein 1/histone deacetylase 4-nucleosome remodeling and deacetylase complex regulates phosphatase and tensin homolog gene expression and function. PMID: 22700976
    17. The fine coordination between MTA1 and p53 in pachytene spermatocytes upon hyperthermal stimulation, was investigated. PMID: 22022494
    18. findings suggest that MTA1 status plays an important role in conferring an optimal cytokine response in mice following infection with Opisthorchis viverrini and is a major player in parasite-induced cholangiocarcinoma in humans PMID: 21725997
    19. The metastasis-associated protein-1 gene encodes a host permissive factor for schistosomiasis, a leading global cause of inflammation and cancer. PMID: 21488078
    20. Gene profiling of MTA1 identifies novel gene targets and functions. PMID: 21364872
    21. findings reveal an obligatory coregulatory role of MTA1 in the regulation of TG2 expression and of the MTA1-TG2 pathway, at least in part, in LPS modulation of the NF-kappaB signaling in stimulated macrophages PMID: 21156794
    22. Data suggest that the expression of MTA1 protein could be regulated by androgen pathway and closely associated with the postnatal development of the epididymis, and that this gene may play a potential role in sperm maturation and fertility. PMID: 21082030
    23. MTA1 regulation of MyD88 may constitute at least one of the mechanisms by which MTA1 stimulates LPS-induced NF-kappaB signaling in stimulated macrophages. PMID: 20702415
    24. there is a p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway PMID: 20071335
    25. Results suggest an inherent role of the MTA1-p53-p53R2 pathway in DNA damage response in cancer cells. PMID: 19837670
    26. In mature mice, MTA1 expression was seen in cell types that constantly undergo proliferation or self-renewal, such as testis and cell types not constantly engaged in proliferation or self-renewal, such as brain, liver and kidney PMID: 19524276
    27. Assignment of the metastasis-associated gene (Mta1) to mouse chromosome band 12F and the metastasis-associated gene 2 (Mta2) to mouse chromosome band 19B by fluorescence in situ hybridization PMID: 11856890
    28. Mta1 interacts with endophilin 3, the site of interaction is suggested to be the SH-3-binding domain of Mta1 and SH-3 domain of endophilin 3. PMID: 15978591
    29. The cDNAs of the splicing variants were inserted into green fluorescent protein (GFP) expression vector and the subcellular localization of the GFP-Mta1 fusion proteins were analyzed. PMID: 16445996
    30. structure and antiestrogenic activity of the unique C-terminal, NR-box motif-containing region of MTA1 PMID: 16807247
    31. Mta1 appears during postnatal testis development and this expression may be crucial for spermatogenesis. PMID: 17401724
    32. role for the MTA1 as an upstream modifier of Six3 and indicate that Six3 is a direct stimulator of rhodopsin expression. PMID: 17666527
    33. These results demonstrate the importance of FOG-2/MTA/RbAp interactions for FOG-2-mediated transcriptional repression and further define the molecular interactions between the FOG repression motif and the NuRD complex. PMID: 18067919
    34. Mta1 may operate as a negative modifier of apoptosis by interacting with p53 during gametogenesis. PMID: 18282480
    35. Data describe the expression of metastasis associated protein 1 (MTA1) in the brain of aging mice and its interaction with the estrogen receptor alpha transactivation domain. PMID: 18679832
    36. This study was undertaken to explore the potential role of MTA1 in mouse liver. PMID: 18769059
    37. MTA1 is required for optimum DNA double-strand break repair after ionizing radiation. PMID: 19805145

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  • 亚细胞定位：
    Nucleus. Nucleus envelope. Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules. Primarily localized in the cytoplasm in embryonic tissues. Localization at the nuclear envelope is TPR-dependent.
  • 组织特异性：
    Widely expressed but not in skeletal muscle. Highly expressed in the brain, liver, kidney and cardiac muscle and in mammary tumors.
  • 数据库链接：

    STRING: 10090.ENSMUSP00000105348

    UniGene: Mm.212577