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  4. Recombinant Mouse Mitogen-activated protein kinase kinase kinase 7 (Map3k7)

Recombinant Mouse Mitogen-activated protein kinase kinase kinase 7 (Map3k7)

  • 中文名称：
    小鼠Map3k7重组蛋白
  • 货号：
    CSB-YP013429MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Map3k7重组蛋白
  • 货号：
    CSB-EP013429MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Map3k7重组蛋白
  • 货号：
    CSB-EP013429MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Map3k7重组蛋白
  • 货号：
    CSB-BP013429MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Map3k7重组蛋白
  • 货号：
    CSB-MP013429MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Map3k7; Tak1Mitogen-activated protein kinase kinase kinase 7; EC 2.7.11.25; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-579
  • 氨基酸序列
    MSTASAASSS SSSSASEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIV ATAGNGQPRR RSIQDLTVTG TEPGQVSSRS SSPSVRMITT SGPTSEKPAR SHPWTPDDST DTNGSDNSIP MAYLTLDHQL QPLAPCPNSK ESMAVFEQHC KMAQEYMKVQ TEIALLLQRK QELVAELDQD EKDQQNTSRL VQEHKKLLDE NKSLSTYYQQ CKKQLEVIRS QQQKRQGTS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis.
  • 基因功能参考文献：
    1. TAK1 directly interacts with and phosphorylates alphaTAT1 at Ser237 to critically enhance its catalytic activity. Also TAK1 selectively inhibits AKT to suppress mitogenic and metabolism-related pathways through microtubules-based mechanisms in culture and in vivo. PMID: 29703898
    2. TAK1 inhibits HBV primarily at viral transcription level through activation of MAPK-JNK pathway. PMID: 28045080
    3. we generated the transgenic mouse line with deletion of Tak1 and gain of function of Bmpr1a. This compound mutation leads to more severe craniofacial deformities than each single mutation. PMID: 29411501
    4. Protein expression, processing and secretion occurred abnormally in transgenic mice overexpressing caMAP3K7. The overexpression of caMAP3K7 had a profound effect on enamel structure by disrupting the orderly growth of enamel prisms. PMID: 29024853
    5. It is a key regulator of the toll-like receptor signaling pathway. PMID: 29027124
    6. The conversion of Tak1-B to Tak1-A consistently led to significant accumulation of lipids in cultured AML12cells, as well as the dysregulation of several lipid metabolism-related genes in mouse liver. Different functional properties of the two isoforms may explain the conflicting functions previously reported for Tak1. PMID: 29475001
    7. demonstrate the efficiency of ad--siRNA-TAK1 in controlling joint inflammation of Collagen-Induced Arthritis, which is associated with the suppression of the expression of pro-inflammatory cytokines and JNK activation. PMID: 28220341
    8. These data, in addition to the fact that Map3k7 is upregulated in the sinus venous-the source of cells for the SAN-suggest that Map3k7 may be an endogenous regulator of the SAN fate PMID: 29281682
    9. These results present a novel in vivo function, the negative role of TAK1 in marginal zone B-cell development that is likely associated with NF-kappaB2 activation. PMID: 27121163
    10. Tnfr1 deletion partially restored thymic and lung macrophages. PMID: 28182011
    11. TAK1 is required for PPARgamma transactivation and promotes PPARgamma transcriptional activity synergistically with TAK1 binding protein 1 (TAB1). PMID: 27293199
    12. inhibition of TAK1 triggered two caspase 8 activation pathways through the induction of RIP1-FADD-caspase 8 complex as well as FLIP cleavage/degradation. PMID: 27685625
    13. TAK1 regulates Nrf2 through modulation of Keap-p62/SQSTM1 interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium. PMID: 27245349
    14. Mekk1 (encoded by Map3k1) signaling activates Mapks to regulate Cdkn1b (encoding p27(Kip1)) expression and p27(Kip1)-dependent proliferative expansion in response to antigen. PMID: 27246297
    15. TRADD knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1/p38 MAPK but not AKT phosphorylation PMID: 28013046
    16. this study demonstrates a pivotal role of TAK1 in dendritic cells in controlling trichloroethylene-induced contact hypersensitivity response and suggests that targeting TAK1 function in DCs may be a viable approach to preventing and treating TCE-related occupational health hazards PMID: 27473013
    17. The E3 ligase TRIM8 is a potent regulator that exacerbates steatohepatitis and metabolic disorders dependent on its binding and ubiquitinating capacity on transforming growth factor-beta-activated kinase 1. PMID: 27981609
    18. Angiotensin-II up-regulates the Ampkalpha1 isoform in renal tissue. Ampkalpha1 participates in renal Tak1 activation and Tak1-dependent signaling induced by angiotensin-II. PMID: 27230958
    19. TRIM8 could promote K63-linked polyubiquitination of transforming growth factor beta-activated kinase 1 (TAK1), leading to the activation of TAK1 and enhanced inflammatory responses. PMID: 27995356
    20. TAK1 signaling preserved the viability of lambda-chain-positive B cells by maintaining Bcl-2 expression through IKK-NF-kappaB signaling PMID: 27696624
    21. Data show that TGFbeta-activated kinase-1 (TAK1) activated nuclear factor of activated T-cells (NFAT)/NF-kappa B (NFkappaB), downregulated BCL2-adenovirus E1B interacting protein 3 (Bnip3), and inhibited cardiac cell death. PMID: 26564789
    22. Crucial functions of inflammatory TAK1-NEMO signaling in protecting the brain endothelium and maintaining normal brain function. PMID: 26347470
    23. Roles of TAK1 in vascular oxidative stress and its contribution to neointima formation after vascular injury. PMID: 25050617
    24. Inactivation of TAK1 in satellite cells inhibits muscle regeneration in adult mice. PMID: 26648529
    25. our current study highlighted the emerging role of TAK1 in configuring the gut-specialized T cell subset, which regulates mucosal homeostasis under lymphopenic conditions. PMID: 26132627
    26. Results provide evidence that TAK1 is required for the activation of NF-kappaB in thymocytes and suggest that TAK1 plays a central role in both innate and adaptive immunity. PMID: 16857737
    27. TAK1 is essential for connective tissue deposition in the dermis. PMID: 23340735
    28. Tak1 functions to regulate tongue development by controlling Fgf10 expression and could represent a candidate gene for mutation in human PRS clefting. PMID: 23460641
    29. In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation. PMID: 23505428
    30. Tak1 provides a critical point of intersection in a complex dialogue between the canonical and noncanonical arms of TGF-beta superfamily signaling required for normal craniofacial development. PMID: 23546880
    31. HnRNP K-3' UTR complex inhibits TAK1 mRNA translation. PMID: 24751651
    32. Loss of TAK1 is associated with delayed axon speciation and outgrowth. PMID: 24963009
    33. Transforming growth factor beta-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling. PMID: 25278099
    34. Tak1 deficiency altered the signaling of NF-kappaB, p38MAPK, and Smad1/5/8 and the expression of PU.1, MITF, c-Fos, and NFATc1, suggesting that Tak1 regulates osteoclast differentiation at multiple stages via multiple signaling pathways. PMID: 25418008
    35. cytoplasmic-element-binding control of transforming growth factor beta-activated kinase 1 mRNA translation mediates the inflammatory immune response PMID: 25452303
    36. Increased expression of myostatin in heart muscle cells caused interstitial fibrosis via activation of the TAK-1-MKK3/6-p38 signaling pathway PMID: 25725788
    37. TAK1 functions as a critical regulator of the phosophorylation status of various cellular proteins that govern osteoclastogenesis PMID: 26102028
    38. TAK1 and IKK2 are novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases. PMID: 26353931
    39. Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation PMID: 26189595
    40. These results suggest a crucial role for TAK1 for maintaining the survival of committed regulatory T cells under physiological conditions. PMID: 25891214
    41. A possible mechanism by which tomoregulin-1 regulates the development of cardiac hypertrophy in TAC-induced cardiac hypertrophy is through inhibiting TGFbeta non-canonical (TAK1-JNK) pathways in the myocardium. PMID: 26092120
    42. TAK1 regulates osteoclastogenesis by integrating activation of NF-kappaB and derepression of NOTCH/RBPJ in myeloid cells through inhibition of NUMBL. PMID: 25535389
    43. Epithelium-specific Tak1:Smad4- and Trim33:Smad4-double mutants display reduced expression of Mmp13 in palatal medial edge epithelial cells. PMID: 25523394
    44. TAK1 regulates hepatic lipid metabolism and tumorigenesis via the AMPK/mTORC1 axis, affecting both autophagy and PPARalpha activity. PMID: 24983318
    45. Nef markedly activated TAK1 in M-CSF-derived M2-MPhi but not in GM-CSF-derived M1-MPhi. PMID: 24874739
    46. TAK1 signaling has a crucial role in podocyte differentiation and attainment of normal glomerular microvasculature during kidney development and glomerular filtration barrier homeostasis. PMID: 24652804
    47. TPL2 mediates TAK1 axis of IL-17 signaling, thereby promoting autoimmune neuroinflammation. PMID: 24980047
    48. Data indicate that GADD34 is the regulatory subunit of rotein phosphatase-1 (PP1) to specify PP1 to dephosphorylate TGF-beta-activated kinase 1 (TAK1) Ser412. PMID: 24534530
    49. Results establish TAK1 as an AMPKalpha1 kinase that regulates vascular endothelial growth factor-induced and cytokine-induced angiogenesis by modulating SOD2 expression and the superoxide anion:hydrogen peroxide balance. PMID: 24072697
    50. The results of this study found TAK1 to be pivotal in CNS autoimmunity, and we present a tool for future investigations of microglial function in the CNS. PMID: 24077561

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 数据库链接：

    KEGG: mmu:26409

    STRING: 10090.ENSMUSP00000040307

    UniGene: Mm.258589