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  4. Recombinant Mouse Multidrug and toxin extrusion protein 1 (Slc47a1), partial

Recombinant Mouse Multidrug and toxin extrusion protein 1 (Slc47a1), partial

  • 货号：
    CSB-YP814291MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP814291MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP814291MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP814291MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP814291MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc47a1
  • Uniprot No.：
  • 别名：
    Slc47a1; Mate1; Multidrug and toxin extrusion protein 1; MATE-1; mMATE-1; Solute carrier family 47 member 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.
  • 基因功能参考文献：
    1. Tissue concentration based investigations using [(11)C]metformin by PET enables the functional analysis of MATEs in the liver and kidneys PMID: 25715695
    2. Mate1 mRNA expression was decreased in mice with either the ob/ob model or the methionine/choline deficiency model of nonalcoholic steatohepatitis. PMID: 26016715
    3. MATE1 was highly expressed in peroxisomes and the endoplasmic reticulum as well as in plasma membranes in the liver and intestine. PMID: 25241911
    4. [(11)C]Metformin may be useful as a PET probe to non-invasively study the in vivo function of hepatobiliary transport and drug-drug interactions, mediated by MATE1 in future clinical investigations. PMID: 24238901
    5. Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein. PMID: 22722930
    6. Homozygous MATE1 variant could be one of the risk factors for metformin-induced lactic acidosis. PMID: 22242910
    7. MATE1 mediates the efflux of cisplatin and is involved in cisplatin-induced nephrotoxicity. PMID: 20813096
    8. The purpose of this study was to evaluate the effects of heterozygous MATE variants on the disposition of metformin in mice and humans. PMID: 20016398
    9. mMATE1 is polyspecific H(+)/(organic cation)OC exchanger. Unexpectedly wide distribution of mMATE1 suggests involvement in diverse biological functions other than excretion of OCs from the body. (Multidrug and toxin extrusion 1, MATE1) PMID: 16641166
    10. mMATE1b is a functional variant of mMATE1 and seems to be the true counterpart to other MATE1 transporters PMID: 17983590
    11. MATE1 mRNA levels were highest in the kidney, where male expression was higher than female. PMID: 18573474
    12. This is the first report to demonstrate an essential role of MATE1 in systemic clearance of metformin. PMID: 19332510

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Predominantly localized to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver).
  • 蛋白家族：
    Multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family
  • 组织特异性：
    Predominantly expressed in kidney and liver. Also expressed in various cells, including brain glia-like cells and capillaries, pancreatic duct cells, urinary bladder epithelium, adrenal gland cortex, heart, stomach, small intestine, thyroid gland, testes,
  • 数据库链接：

    KEGG: mmu:67473

    STRING: 10090.ENSMUSP00000010267

    UniGene: Mm.100741