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  4. Recombinant Mouse Muscular LMNA-interacting protein (Mlip)

Recombinant Mouse Muscular LMNA-interacting protein (Mlip)

  • 中文名称：
    小鼠Mlip重组蛋白
  • 货号：
    CSB-YP705057MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mlip重组蛋白
  • 货号：
    CSB-EP705057MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mlip重组蛋白
  • 货号：
    CSB-EP705057MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mlip重组蛋白
  • 货号：
    CSB-BP705057MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mlip重组蛋白
  • 货号：
    CSB-MP705057MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mlip
  • Uniprot No.：
  • 别名：
    Mlip; CipMuscular LMNA-interacting protein; Cardiac Isl1-interacting protein; CIP; Muscular-enriched A-type laminin-interacting protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-269
  • 氨基酸序列
    MEFGKHEPGS SLKRNKNLEE GVTFEYSDHM TFSSESKQER VQRILDYPSE VSGRNSQQKE FNTKEPQGMQ KGDLFKAEYV FIVDSDGEDE ATCRQGEQGP PGGPGNIATR PKSLAISSSL ASDVVRPKVR GADLKTSSHP EIPHGIAPQQ KHGLALDEPA RTESNSKASV LDLPVEHSSD SPSRPPQTML GSETIKTPTT HPRAAGRETK YANLSSSSST ASESQLTKPG VIRPVPVKSK LLLRKDEEVY EPNPFSKYLE DNSGLFSEQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD.
  • 基因功能参考文献：
    1. Deletion of the CIP-encoding gene accelerated progress from hypertrophy to heart failure in several cardiomyopathy models. PMID: 26436652
    2. Mlip-deficient hearts showed an impaired capacity to adapt to stress (isoproterenol-induced hypertrophy), likely because of deregulated Akt/mTOR activity. PMID: 26359501
    3. studies identify cardiac Isl1-interacting protein (CIP) as a novel regulator of cardiac hypertrophy. PMID: 22343712
    4. MLIP is expressed most highly in striated and smooth muscle, it is likely to contribute to the mesenchymal phenotypes of laminopathies. PMID: 21498514
  • 亚细胞定位：
    Nucleus. Nucleus envelope. Nucleus, PML body. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
  • 组织特异性：
    Ubiquitous but more abundantly expressed in heart, skeletal and smooth muscle (at protein level). In brain, expressed by a subpopulation of cells within the hippocampus and cortex. In heart, expressed by ventricular cardiomyocytes. Expression is highly re
  • 数据库链接：

    KEGG: mmu:69642

    STRING: 10090.ENSMUSP00000034910

    UniGene: Mm.35008