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  4. Recombinant Mouse Musculin (Msc)

Recombinant Mouse Musculin (Msc)

  • 货号：
    CSB-YP015025MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015025MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015025MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015025MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015025MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Msc
  • Uniprot No.：
  • 别名：
    Msc; MyorMusculin; Myogenic repressor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-201
  • 氨基酸序列
    MSTGSVSDPE DSEMRGLQRV YPAPASKRPP LLRMERGYGS PSDISSAEEE DGEEEPGSLG AAGGCKRKRL RGADAGGAGG RAGGAGKKPL PPKGSAAECK QSQRNAANAR ERARMRVLSK AFSRLKTSLP WVPPDTKLSK LDTLRLASSY IAHLRQLLQE DRYEDSYVHP VNLTWPFVVS GRPDSDSKDV SAANRLCGTS A
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription repressor that blocks myogenesis and activation of E-box dependent muscle genes.
  • 基因功能参考文献：
    1. this study shows that MSC-deficient TGFb-induced Treg cells are unable to suppress Th2 cell responses, and that MSC-deficient mice spontaneously develop gut and lung inflammation with age PMID: 28114290
    2. MyoR modulates cardiac conduction by repressing Gata4. PMID: 25487574
    3. MyoR is a transcription factor selectively up-regulated in CD4 T cells during Tfh cell differentiation PMID: 24386375
    4. results demonstrate that ABF-1 facilitates formation of memory B cells but prevents plasma cell differentiation. PMID: 25070843
    5. Basic helix-loop-helix transcriptional factor MyoR regulates BMP-7 in acute kidney injury. PMID: 23515721
    6. Data show that correct levels of expression of Myf5 and MyoD during mouse craniofacial development result from activation by musculin and TCF21 through direct binding to specific enhancers. PMID: 22318627
    7. a feed-forward loop where MyoD indirectly down-regulates MyoR via miR-378 PMID: 21471220
    8. findings identify MyoR and capsulin as unique transcription factors for the development of specific head muscles PMID: 12493912
    9. MyoR may serve as a repressor of embryonal endoderm differentiation. PMID: 15554945
    10. Our results suggest that musculin/MyoR may play important roles not only in developmental processes but also in regenerative processes in adult tissue. PMID: 15967813
    11. Induction of Musculin is responsible for the rapid down-regulation of MyoD at 4-5 days during staged regeneration. PMID: 16500621
    12. Musclin binds to NPR3 competitively with ANP and may affect ANP concentrations in a local or systemic manner. PMID: 19244276

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:17681

    STRING: 10090.ENSMUSP00000027062

    UniGene: Mm.5820