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  4. Recombinant Mouse Myb-related protein A (Mybl1)

Recombinant Mouse Myb-related protein A (Mybl1)

  • 中文名称：
    小鼠Mybl1重组蛋白
  • 货号：
    CSB-YP015263MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mybl1重组蛋白
  • 货号：
    CSB-EP015263MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mybl1重组蛋白
  • 货号：
    CSB-EP015263MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mybl1重组蛋白
  • 货号：
    CSB-BP015263MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mybl1重组蛋白
  • 货号：
    CSB-MP015263MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mybl1
  • Uniprot No.：
  • 别名：
    Mybl1; Amyb; Myb-related protein A; A-Myb; Myb-like protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-751
  • 氨基酸序列
    MAKRSRSEDE DDDLQYADHD YEVPQQKGLK KLWNRVKWTR DEDDKLKKLV EQHGTDDWTL IASHLQNRSD FQCQHRWQKV LNPELIKGPW TKEEDQRVIE LVQKYGPKRW SLIAKHLKGR IGKQCRERWH NHLNPEVKKS SWTEEEDRII YEAHKRLGNR WAEIAKLLPG RTDNSIKNHW NSTMRRKVEQ EGYLQDGIKS ERSSSKLQHK PCATMDHLQT QNQFYIPVQI PGYQYVSPDG NCVEHVQTSA FIQQPFVDED PDKEKKIKEL ELLLMSAENE VRRKRLPPQP GSFSSWSGSF LMDDSMSNTL NNLEEHTTEF YSMDENQTVS AQQNSPTKFL AVEANAVLSS LQTIPEFPRT LELIESDPVA WSDVTSFDLS DAAASPVKST PVKLMRIQHN EGAMECQFNV SLVLEGKKNS RNGGDSEAIP LTSPNVVKFS TPPTISRKKK RIRVGQSAGS ELGSASLSEV GNRRIKHTPV KTLPFSPSQF FNTCPGNEQL NIENPSFTST PICGQKVLIT TPLQKEATPK DQKENVGFRT PTIRRSILGT TPRTPTPFKN ALAAQEKKYG PLKIVSQPLA FLEEDIREVL KEETGTDIFL KEEDEPAYKS CKQEHSASVK KVRKSLALES WDKEEPGTQL LTEDISDMQS ENILTTSLLM IPLLEIHDNR CNLTPEKQDI NSANKTYTLN KKRPNPNPCK AVKLEKSLQS NCEWETVVYG KTEDQLIMTE QARRYLSTYT ATSSTSRALI L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism, such as PIWIL1. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Transcriptional activator of SOX30.
  • 基因功能参考文献：
    1. A-MYB regulation of piRNA pathway proteins and piRNA genes creates a coherent feedforward loop that ensures the robust accumulation of pachytene piRNAs during early meiosis in mouse testes. PMID: 23523368
    2. A-MYB (MYBL1) stimulates murine testis-specific Ldhc expression via the cAMP-responsive element (CRE) site. PMID: 21998171
    3. Results reveal that MYBL1 is a master regulator of meiotic genes that are involved in multiple processes in spermatocytes, particularly those required for cell cycle progression through pachynema. PMID: 21750041
    4. RFX2 is potentially an important transcriptional regulator in pachytene spermatocytes; Rfx2 itself is a good candidate to be regulated by A-MYB, which is essential for meiotic progression. PMID: 20003220
    5. A-myb plays a role in the reactive gliosis signaling pathway in kainic acid-induced excitotoxic lesions PMID: 17053967

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Predominantly in the testis. Very low levels in the ovaries, spleen and brain.
  • 数据库链接：

    KEGG: mmu:17864

    STRING: 10090.ENSMUSP00000086034

    UniGene: Mm.459569