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  4. Recombinant Mouse Myogenic factor 6 (Myf6)

Recombinant Mouse Myogenic factor 6 (Myf6)

  • 中文名称：
    小鼠Myf6重组蛋白
  • 货号：
    CSB-YP015288MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Myf6重组蛋白
  • 货号：
    CSB-EP015288MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Myf6重组蛋白
  • 货号：
    CSB-EP015288MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Myf6重组蛋白
  • 货号：
    CSB-BP015288MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Myf6重组蛋白
  • 货号：
    CSB-MP015288MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Myf6
  • Uniprot No.：
  • 别名：
    Myf6; Mrf4; Myf-6; Myogenic factor 6; Myf-6; Herculin; Muscle-specific regulatory factor 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-242
  • 氨基酸序列
    MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPQ EAGSDSSGEE HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL RERRRLKKIN EAFEALKRRT VANPNQRLPK VEILRSAISY IERLQDLLHR LDQQEKMQEL GVDPYSYKPK QEILEGADFL RTCSPQWPSV SDHSRGLVIT AKEGGANVDA SASSSLQRLS SIVDSISSEE RKLPSVEEVV EK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
  • 基因功能参考文献：
    1. findings identified miR-374b directly targets Myf6 and negatively regulates myogenesis PMID: 26498529
    2. Mrf4 has a role in priming embryonic founder cells to become adult muscle stem cells PMID: 23623977
    3. Intrinsic muscle factor MRF4 plays an important role in maintenance of neuromuscular junctions. PMID: 21278612
    4. Data demonstrated that Myf6 is Tceal7 upstream transactivators using transcriptional assays. PMID: 20307260
    5. MRF4 targets the proximal region of M-cadherin promoter and bind the E4-box. PMID: 20334626
    6. Mrf4 expression precedes or is contemporaneous with that of Myf5, suggesting that this transcription factor plays a hitherto unsuspected role in myogenesis PMID: 12204280
    7. an enhancer element directs MRF4 gene expression primarily in fast muscle fibers PMID: 12435381
    8. elements within a 7.5-kb promoter fragment of the MRF4 gene are sufficient to drive the embryonic wave of expression very similar to the endogenous gene in somites of mouse embryos PMID: 15282164
    9. Expression of the Na(V) 1.4 Na+ channel was substantially reduced in MRF4-null mice, both in the surface membrane and at neuromuscular junctions. Thus, MRF4 appears to play a novel and selective role in adult muscle. PMID: 16358417
    10. Taken together, these results indicate that MRF4 and MyoD play competitive roles in myogenesis by stimulating cell proliferation and differentiation, respectively. PMID: 17959144

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Skeletal muscle.
  • 数据库链接：

    KEGG: mmu:17878

    STRING: 10090.ENSMUSP00000047529

    UniGene: Mm.11