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  4. Recombinant Mouse N-terminal EF-hand calcium-binding protein 3 (Necab3)

Recombinant Mouse N-terminal EF-hand calcium-binding protein 3 (Necab3)

  • 中文名称：
    小鼠Necab3重组蛋白
  • 货号：
    CSB-YP863526MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Necab3重组蛋白
  • 货号：
    CSB-EP863526MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Necab3重组蛋白
  • 货号：
    CSB-EP863526MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Necab3重组蛋白
  • 货号：
    CSB-BP863526MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Necab3重组蛋白
  • 货号：
    CSB-MP863526MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Necab3
  • Uniprot No.：
  • 别名：
    Necab3; Apba2bp; Xb51; N-terminal EF-hand calcium-binding protein 3; Amyloid-beta A4 protein-binding family A member 2-binding protein; X11L-binding protein 51; mXB51
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-353
  • 氨基酸序列
    MACAGLLTVC LLGPPAPQQP RHSAPAAGHA LFQDVFRRAD KNDDGKLSFE EFQNYFADGV LSSAELRELF SGIDDHLTDN LETEKLCDYF STHLGVYRPV LAALESLNRA VLTAMDTTKL EYEQASKVDQ FVTRFLLRET VNQLQALQTS LEGASDTLEA QAHGQRLDEE TIKAQSRPCG SRRAGRRALR SISWSPSWSP GSSDTGRSSE AEQQWRLQVN RLQELIDQLE CKAPRLEPTH EEDLTKGFDS HILVAQRQVQ VAEDALQDFH RALCCYMNFT GAQSHCLHVS AQKMLDNAAF TLYEFWQDEA SWRRHQQSPC SKAFQRTLID HLQAPDTLTT VFFPASWWIM NNN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3.
  • 基因功能参考文献：
    1. The genes for the three Necab's, including Necab-3, were expressed in specific, non-overlapping areas of the hippocampus. PMID: 23850650
    2. Physical interactions of Nek2 with NIP1 were confirmed. In fact, Nek2 can phosphorylate NIP1 in vivo. Immunostaining experiments revealed that NIP1 is a Golgi protein. PMID: 14697346
    3. xb51 may be required for maturation and maintenance of xb51-expressing neurons in the forebrain PMID: 19035353
  • 亚细胞定位：
    Golgi apparatus.
  • 组织特异性：
    Widely expressed, with highest levels in the brain.
  • 数据库链接：

    KEGG: mmu:56846

    STRING: 10090.ENSMUSP00000000895

    UniGene: Mm.143748