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  4. Recombinant Mouse Nanos homolog 3 (Nanos3)

Recombinant Mouse Nanos homolog 3 (Nanos3)

  • 货号：
    CSB-YP015438MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015438MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015438MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015438MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015438MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nanos3
  • Uniprot No.：
  • 别名：
    Nanos3; Nos3; Nanos homolog 3; NOS-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-178
  • 氨基酸序列
    MGTFNLWTDY LGLARLVGAL HKEEELDVRL DPKPEPKPSS ESQQASKESS AAPERLCSFC KHNGESRAIY QSHVLKDEAG RVLCPILRDY VCPQCGATQE HAHTRRFCPL TSQGYTSVYC YTTRNSAGKK LTRPDKAKTQ DAGHRLGGEA AAGVYAGSKS GRKPPGPSPS ACCPSTTA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.
  • 基因功能参考文献：
    1. NANOS3 mutation is one possible cause of primary ovarian insufficiency. PMID: 24091668
    2. Study suggests that Nanos3-3'UTR has an essential role in translational control in embryo. PMID: 20174582
    3. Report distinct posttranscriptional regulations in primordial germ cells soon after their specification, for which RNA-binding proteins such as NANOS3 would play critical functions. PMID: 19861488
    4. cloning and functional analyses of nanos2 and nanos3; demonstrated an evolutionarily conserved function of nanos proteins in germ cell development [nanos2] [nanos3] PMID: 12947200
    5. eNOS is the main isoform influencing the initiation of caerulein-induced AP. eNOS-derived NO exerts a protective effect through actions on nonacinar cell types, most likely endothelial cells, to produce greater pancreatic microvascular blood flow. PMID: 14962849
    6. Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population is reported. PMID: 18089289
    7. Results suggest that Nanos3 maintains the germ cell lineage by suppressing both Bax-dependent and Bax-independent apoptotic pathways. PMID: 18436203
    8. detection of the germ cell-specific proteins Nanos2 and Nanos3 as markers of spermatogonia has enabled the clear dissection of complex populations of these cells as Nanos2 was recently shown to be involved in the maintenance of stem cells PMID: 19818747

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, P-body.
  • 蛋白家族：
    Nanos family
  • 组织特异性：
    Expressed in undifferentiated spermatogonial cells.
  • 数据库链接：

    KEGG: mmu:244551

    STRING: 10090.ENSMUSP00000067385

    UniGene: Mm.216740