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  4. Recombinant Mouse Neurogenin-2 (Neurog2)

Recombinant Mouse Neurogenin-2 (Neurog2)

  • 中文名称：
    小鼠Neurog2重组蛋白
  • 货号：
    CSB-YP015731MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Neurog2重组蛋白
  • 货号：
    CSB-EP015731MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Neurog2重组蛋白
  • 货号：
    CSB-EP015731MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Neurog2重组蛋白
  • 货号：
    CSB-BP015731MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Neurog2重组蛋白
  • 货号：
    CSB-MP015731MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Neurog2
  • Uniprot No.：
  • 别名：
    Neurog2; Ath4a; Atoh4; Ngn2; Neurogenin-2; NGN-2; Helix-loop-helix protein mATH-4A; mATH4A; Protein atonal homolog 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-263
  • 氨基酸序列
    MFVKSETLEL KEEEEVLMLL GSASPASATL TPMSSSADEE EDEELRRPGS ARGQRGAEAE QGVQGSPASG AGGCRPGRLL GLMHECKRRP SRSRAVSRGA KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK IETLRFAHNY IWALTETLRL ADHCAGAGGL QGALFTEAVL LSPGAALGAS GDSPSPPSSW SCTNSPASSS NSTSPYSCTL SPASPGSDVD YWQPPPPEKH RYAPHLPLAR DCI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
  • 基因功能参考文献：
    1. data support the hypothesis that Neurog2 acts at the top of a retinal bHLH transcription factor hierarchy. Neurog2 simultaneously promotes terminal cell cycle exit and retinal ganglion cell differentiation. PMID: 29770538
    2. s conclude that the Neurog2 gene is expressed and active prior to birth, but also exerts an influence on postnatal retinal neuron differentiation. PMID: 30048641
    3. Neurog2 and Ascl1 altered the expression of Ikaros and Foxg1. PMID: 28584103
    4. data suggest that common reprogramming mechanisms exist driving the conversion of lineage-distant somatic cell types to neurons and reveal a critical role for CEND1 in NEUROG2-driven astrocytic reprogramming. PMID: 26321141
    5. Findings suggest the strict spatio-temporal expression of Notch effector genes plays an important role during hippocampal neurogenesis and suggests that Notch1, Hes1 and Ngn2 were regulated by changing some specific CpG sites of their promoters. PMID: 25701255
    6. IFN-gamma inhibits neuronal differentiation of neural progenitor cells by negatively regulating the expression of Neurog2 via the JAK/STAT1 pathway. PMID: 26325468
    7. In mid-embryonic neocortical walls, expression of Neurog2-d4Venus mostly overlapped with that of Neurog2 protein, with a slightly (1 h) delayed onset. PMID: 24712911
    8. APP-stimulated neuronal differentiation of NSPCs is mediated by Ngn2 PMID: 25217641
    9. Notch signaling controls the overall tempo of retinogenesis through Atoh7 and Neurog2, by integrating cell fate specification, the wave of neurogenesis and the developmental status of cells ahead of this wave PMID: 25100656
    10. Neurog1 and Neurog2 have unique and redundant functions in the piriform cortex, controlling the timing of differentiation of neurons PMID: 24403153
    11. Neurog2 functions as a transcriptional activator to initiate the expression of several genetic off-switches, each of which repress distinct gene expression programs during neocortical development. PMID: 22735158
    12. Sustained vs. oscillating expressions of Ngn2, Dll1 and Hes1: a model of neural differentiation of embryonic telencephalon. PMID: 23499991
    13. Neurog1/2 together coordinate development of the olfactory system, which depends on tissue interactions between the olfactory bulb and epithelium. PMID: 22906231
    14. Gene expression analyses revealed that Ngn2-induced in vitro differentiation partially resembled neurogenesis in vivo, as it included specific activation of Ngn2 target genes and interaction partners PMID: 22719915
    15. Neurogenin 1 expression in mouse embryonic stem (ES) cells promotes neural differentiation and inhibits proliferation, thus establishing an approach to graft ES cells safely into the spinal cord. PMID: 22245661
    16. Loss of microprocessor activity results not only in an increase Ngn2 protein but also extended expression of Neurog2 into later stages of the neurogenic lineage. PMID: 22706270
    17. It was shown that, in the cerebellar primordium, neurogenin 2 is expressed by cycling progenitors fated to become Purkinje cells. During cerebellar development, neurogenin 2 is expressed in G1 phase by progenitors poised to exit the cell cycle. PMID: 22669821
    18. temporal regulation of neurogenin 2 heterodimerization by GSK3 is a central component of the neuronal differentiation "clock" that coordinates the timing and tempo of neocortical neurogenesis in mouse PMID: 22674256
    19. the formation of cranial ganglia along the anterior-posterior axis is dependent on the dynamic spatiotemporal activities of Neurog1 and/or Neurog2 in both neural crest and epibranchial placode. PMID: 22102600
    20. Data show that Bmp7 regulates Ngn2 steady-state transcript levels in the E14.5 cortex. PMID: 22461901
    21. Ngn2 is required for the coordinated specification of cardinal features defining the phenotype of cortical pyramidal neurons, including their migration properties, dendritic morphology and axonal projection. PMID: 21864333
    22. NeuroD promoter is substantially more sensitive to the phosphorylation status of Ngn2 than the Delta promoter, and that this can be attributed to differences in the ease of promoter activation. PMID: 22491944
    23. multi-site cdk-dependent phosphorylation of Ngn2 interprets cdk levels to control neuronal differentiation in response to cell cycle lengthening during development PMID: 21852393
    24. Results indicate that LMO4 promotes the acquisition of cortical neuronal identities by forming a complex with NGN2 and subsequently activating NGN2-dependent gene expression. PMID: 21652654
    25. all subtypes of glutamatergic neurons derive from Neurog2 positive progenitors during development of the olfactory bulb PMID: 21466690
    26. Neurog2 controls the leading edge of neurogenesis in the mouse retina. PMID: 20144606
    27. localization of neurogenin2, NeuroD and Mash 1 in the embryonic forebrain is highly similar to the situation described in Xenopus and zebrafish, suggesting a temporally and spatially defined control of neurogenesis during development PMID: 20058311
    28. Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate. PMID: 12060754
    29. neurogenin 2 developmental expression is regulated by Pax-6 PMID: 12783797
    30. Neurogenin2 determines the projection of thalamic neurons to specific cortical domains by specifying the responsiveness of their axons to cues encountered in an intermediate target, the ventral telencephalon. PMID: 12895419
    31. Sequential phases of cortical specification involve ngn2-dependent and -independent pathways. PMID: 15229646
    32. identified several new components of the neocortex differentiation cascade(s) activated downstream of Ngn1 and Ngn2 PMID: 15328020
    33. Neuron pairs showed uneven/asymmetric expression of NGN2 whereas other pairs were either symmetrically positive or negative. PMID: 15523634
    34. Olig2/Ngn2 ratio in motor neuron progenitor cells serves as a gate for timing proper gene expression during the development. PMID: 15655114
    35. In the absence of Ngn2, there is an increase in the number of dorsal neuronal populations dI3 and dI5 neurons, in contrast to the effects produced by activity of achaete-scute complex homolog-like 1 PMID: 15901662
    36. Ngn2 coordinates the acquisition of the radial migration properties and the unipolar dendritic morphology characterizing pyramidal neurons through molecular mechanisms distinct from those mediating its proneural activity. PMID: 16202708
    37. These data indicate that retinal neurons expressing ngn2 at some point in their life histories may later differentiate into a variety of cell types. PMID: 16364654
    38. Data show that lack of neurogenin (Ngn)2 impairs the development of mesencephalic dopaminergic (mesDA) neurons, such that less than half of the normal mesDA neuron number remain in Ngn2 mutant mice at postnatal stages. PMID: 16396906
    39. These results demonstrate that neurogenin 2 is uniquely required for the development of midbrain dopaminergic neurons. PMID: 16410412
    40. BMP and FGF-2 act as positive and negative regulators in ngn-2 expression, respectively; these signaling molecules regulate the differentiation of sensory neurons and glia. PMID: 16425218
    41. Over-expression of Nurr1 and Ngn2 in combination generates morphologically mature TH-expressing neurons that also express additional mesencephalic markers. PMID: 17291494
    42. Ngn2 transient expression in proliferating neuronal progenitors supports the idea that it plays a significant role in adult neurogenesis. PMID: 17466019
    43. Helt determines GABAergic over glutamatergic fate, by repressing Ngn genes; Helt and Ngns are commonly used in the mesencephalon for determination of the GABAergic versus glutamatergic transmitter phenotype. PMID: 17611227
    44. The proneural gene Ngn2 instructs a partial cortical identity when misexpressed in ventral telencephalic progenitors. PMID: 18160702
    45. Rat and mouse species-dependent differences of Nurr1 and Ngn2 actions in dopamine neuron differentiation. PMID: 18242186
    46. Pax3 regulates Hairy and enhancer of split homolog-1 (Hes1) and Neurogenin2 (Ngn2) by directly binding to their promoters. PMID: 18308300
    47. Novel targets of Ngn2 were identified, such as members of the Notch and Wnt pathways, and proteins involved in adhesion and signal transduction. PMID: 18377642
    48. The phoshorylation of neurogenin 2 at S231 and S234 facilitates the interaction of neurogenin 2 with homeodomain transcription factors to specify motor neuron identity. PMID: 18400164
    49. Data establish a unique role of Ngn2 in DG neurogenesis during development and raise the possibility that Ngn2 has a similar function in adult neurogenesis. PMID: 18448566
    50. Ngn1, Ngn2 and Mash1 are expressed at relevant stages of cerebellar neurogenesis in the prospective cerebellar nuclei and in the ventricular zone PMID: 18498101

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:11924

    STRING: 10090.ENSMUSP00000029587

    UniGene: Mm.42017