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  4. Recombinant Mouse Neurogranin (Nrgn)

Recombinant Mouse Neurogranin (Nrgn)

  • 货号：
    CSB-YP016081MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP016081MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP016081MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP016081MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP016081MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nrgn
  • Uniprot No.：
  • 别名：
    NrgnNeurogranin; Ng; RC3) [Cleaved into: NEUG(55-78)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-78
  • 氨基酸序列
    MDCCTESACS KPDDDILDIP LDDPGANAAA AKIQASFRGH MARKKIKSGE CGRKGPGPGG PGGAGGARGG AGGGPSGD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates the affinity of calmodulin for calcium. Involved in synaptic plasticity and spatial learning.
  • 基因功能参考文献：
    1. The findings of this study specifically suggest that accumbal Ng plays an essential role in the counterbalance between NMDAR and mGluR5 signaling. PMID: 29225043
    2. The results of this study indicated that elevated neurogranin function within the PFC can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks. PMID: 25972176
    3. Neurogranin knockout mice are hyperactive and socially withdrawn. PMID: 22809330
    4. Ng expression in olfactory bulb is restricted to developmental stages suggesting activity-dependent regulation in a time window critical for glomerular circuit development, suggesting a role for Ng in maturation and dendritic remodeling of tufted cells. PMID: 22592880
    5. findings suggest that mobilization of CaM and Ng to stimulated dendritic spines may enhance synaptic efficacy by increasing and prolonging the Ca2+ transients and activation of Ca2+/CaM-dependent enzymes. PMID: 21256930
    6. We propose that the differential regulation of multiple sense and novel overlapping natural antisense transcripts at the Nrgn and Camk2n1 loci will increase the diversity of posttranscriptional regulation PMID: 20693275
    7. Results provide a new specific neurochemical marker to identify a subpopulation of olfactory granule cells and suggest possible functional implications for neurogranin in olfactory bulb plasticity mechanisms. PMID: 19827160
    8. Data show that Ng displays a strong nuclear localization when expressed in cell lines and hippocampal neurons. PMID: 19751214
    9. Attenuation of protein kinase C and cAMP-dependent protein kinase signal transduction in the neurogranin knockout mouse PMID: 11912190
    10. Neurogranin expression in the cerebellum by brush cells, which are excitatory, shows remarkable cell type- and species-specific expression patterns of a postsynaptic protein mediating calcium signaling mechanisms. PMID: 12655510
    11. calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3 PMID: 12859333
    12. NMDA induced a rapid and transient phosphorylation and oxidation of neurogranin in mouse hippocampal slices PMID: 12950461
    13. NG is expressed by principal cells in different neocortical layers and in the hippocampus by granule cells of the dentate gyrus and pyramidal neurons of CA1-CA3. PMID: 15389613
    14. Results suggest that neurogranin oxidation plays a significant role in intracellular calcium homeostasis, essential for the activated signaling networks in learning and memory. PMID: 15469893
    15. Ng may promote a high [Ca2+]i by a "mass-action" mechanism; namely, the higher the Ng concentration, the more Ng-CaM complexes will be formed. PMID: 15564582
    16. These results suggest that neurogranin protein may be involved in the development of cerebral hypoxic preconditioning. PMID: 16182446
    17. Data suggest that parasagittal stripes of Purkinje cells express neurogranin, possibly from as early as embryonic day (E) 13 and definitively from E15, in a pattern that persists up to postnatal day 20. PMID: 16320235
    18. Neurogranin(Ng) gates neuronal signaling reactions involved in learning and memory. During environmental enrichment, these Ng-regulated reactions are also critical for enhancement of synaptic plasticity and cognitive functions. PMID: 16763030
    19. Recombinant mNg promotes SNP-induced cell death in human cells through an amplification of calcium-mediated signaling, which requires the interaction between CaM and IQ motif of Ng. PMID: 17389928
    20. phosphorylation of neurogranin (Ng) but not the calmodulin/Ng interaction plays an important role in ERK activation PMID: 17505539
    21. long-term enrichment for the aging Ng-/- mice may improve their cognitive function through an Ng-independent plasticity pathway PMID: 17671107
    22. Neurogranin may regulate, in addition to the Ca(2+)-CaM-dependent process, Ca(2+)-sensitive enzymes by influencing the buffering capacity of CaM and subsequently free Ca(2+) levels. PMID: 17959737
    23. The presented data demonstrate that Nrgn can be produced at high levels outside the brain, and suggest a novel oncogenic role in T-cell lymphomas in mice. PMID: 19376211

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  • 亚细胞定位：
    Cytoplasm. Cell junction, synapse. Cell projection, dendritic spine.
  • 蛋白家族：
    Neurogranin family
  • 数据库链接：

    KEGG: mmu:64011

    STRING: 10090.ENSMUSP00000070113

    UniGene: Mm.335065