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  4. Recombinant Mouse Neuroligin-2 (Nlgn2), partial

Recombinant Mouse Neuroligin-2 (Nlgn2), partial

  • 货号：
    CSB-YP718192MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP718192MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP718192MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP718192MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP718192MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nlgn2
  • Uniprot No.：
  • 别名：
    Nlgn2; Kiaa1366; Neuroligin-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures.
  • 基因功能参考文献：
    1. These results demonstrate a significant impact of a single point mutation NL2 R215H on brain functions. PMID: 29859117
    2. At the molecular level NLGN2 colocalizes with its neuronal partner collibystin, a CDC42 guanine nucleotide exchange factor, which is also expressed by endothelial cells and in turn modulates Angiopoietin 2 release. PMID: 29709479
    3. nucleus accumbens neuroligin-2 has a role in depression and stress susceptibility PMID: 29339486
    4. The results of this study confirmed the importance of NL2 as organizer of the GABAergic PSD and unravel distinct roles for alpha1- and alpha2-GABAARs in the formation of GABAergic circuits in close interaction with the dystrophin-glycoprotein complex. PMID: 28643105
    5. findings reveal how unique postsynaptic Cell Adhesion Molecules neuroligin 2 and slitrk3 work in concert to control synaptogenesis and establish a general framework for GABAergic synapse development. PMID: 29107521
    6. Neuroligin 2 deletion predominantly affects inhibitory synapses onto projection neurons in basal amygdala, resulting in decreased inhibitory drive onto these neurons and leading to their excessive activation under anxiogenic conditions. PMID: 26142252
    7. Results indicate that Nlgn2 is required for continuous maintenance of inhibitory synapses in the adult medial prefrontal cortex PMID: 25824299
    8. Results highlight the importance of neuroligin-2 in mediating early-life stress effects on social behavior and social cognition. PMID: 25765754
    9. Neuroligin-2 was essential for maintaining normal climbing-fiber synapse numbers in purkinje cell circuits. PMID: 26291161
    10. Endogenous NL2 undergoes proline-directed phosphorylation at its unique S714-P consensus site, leading to the recruitment of Pin1. This signaling cascade negatively regulates NL2's ability to interact with gephyrin at GABAergic post-synaptic sites. PMID: 25297980
    11. analysis of neuroligin-2 trafficking and proteomics PMID: 25190809
    12. Cholinergic cells express neuroligin 2 in a subset of their input synapses. PMID: 24039767
    13. NL2 also regulates KCC2 to modulate GABA functional switch. PMID: 23663753
    14. Two subsynaptic domains, one containing IgSF9b for synaptic adhesion and the other containing gephyrin and GABAA receptors for synaptic transmission, are interconnected through S-SCAM and neuroligin 2. PMID: 23751499
    15. This study demonistrated that neuroligin-2 as a novel molecule that promotes climbing fibers synapse elimination in postsynaptic Purkinje cells in mice. PMID: 22915109
    16. This study demonstrated for the first time that deletion of NL2 increases excitability of cortical neurons in the hippocampus of intact animals, most likely through impaired GABA(A)R clustering. PMID: 20530218
    17. The data of this study showed that the NL2- and dystroglycan-containing complexes are differentially localized in the presynaptic photoreceptor terminals and suggest that they may serve distinct functions in retina. PMID: 19859968
    18. The neuroligin 2 is as a new cell adhesion protein specific for inhibitory synapses and open new avenues for identifiying the constituents of this unique type of postsynaptic specialization. PMID: 15540461
    19. Data show that neuroligin 2 is required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts. PMID: 16982420
    20. The neuroligin 2 transgenic mice manifested stereotyped jumping behavior, anxiety, impaired social interactions, synaptic imblance. PMID: 18550748
    21. GABA(A) receptors are dispensable for synapse formation and maintenance and for targeting NL2 to inhibitory synapses. PMID: 18723687
    22. NL2 modulates inhibitory synaptic function and deletion of NL2 can lead to a selective behavioral phenotype PMID: 19016888
    23. NL2 is essential for the functional integrity of GABAergic signaling and as a consequence, for information processing in the retina. PMID: 19553444
    24. we identified interactions of neuroligin 2 (NL2) with the key components of the inhibitory postsynaptic scaffold - gephyrin and collybistin; suggest that NL2 functions as an organizer of inhibitory postsynaptic differentiation PMID: 19755106
    25. NL2 deletion decreases the unitary (cell-to-cell) amplitude of inhibitory postsynaptic potentials (IPSP) evoked from single fast-spiking interneurons. PMID: 19889999

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane.
  • 蛋白家族：
    Type-B carboxylesterase/lipase family
  • 组织特异性：
    Brain and arteries. Detected in the retina outer plexiform layer (at protein level). Widely expressed. Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
  • 数据库链接：

    KEGG: mmu:216856

    STRING: 10090.ENSMUSP00000053097

    UniGene: Mm.151293