Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Neuromedin-B (Nmb)

Recombinant Mouse Neuromedin-B (Nmb)

  • 货号：
    CSB-YP863435MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP863435MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP863435MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP863435MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP863435MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nmb
  • Uniprot No.：
  • 别名：
    Nmb; Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    25-56
  • 氨基酸序列
    APFNWD LPEPRSRASK IRVHPRGNLW ATGHFM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stimulates smooth muscle contraction in a manner similar to that of bombesin.
  • 基因功能参考文献：
    1. NMB or NMBR silencing inhibited M-CSF/c-Fms-mediated downstream signaling pathways like activation of ERK and Akt and induction of D-type cyclins, cyclin D1 and D2. PMID: 28780306
    2. Data show that neuromedin B (NMB) expression was higher in the melanocortin 2 receptor MC2R(-/-) than in the wild-type (WT) mice. PMID: 24742195
    3. The majority of dorsal spinal cord Grp is synthesized locally in dorsal spinal cord neurons while Nmb is highly expressed in pain- and itch-sensing dorsal root ganglion neurons. PMID: 22776446
    4. The data demonstrated that the neuromedin B-neuromedian B receptor interaction in pregnant myometrial primary cells in vitro predominantly influenced uterine activity through regulation of Il6 expression via the Rela/p65 pathway. PMID: 22262690
    5. lysosomal degradation of neuromedin B is dependent on tripeptidyl peptidase-I PMID: 15158442
    6. REsults describe the expression of neuromedin B in adipose tissue and its regulation by changes in energy balance. PMID: 17766645

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Bombesin/neuromedin-B/ranatensin family
  • 数据库链接：

    KEGG: mmu:68039

    STRING: 10090.ENSMUSP00000026817

    UniGene: Mm.22246