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  4. Recombinant Mouse Neuroserpin (Serpini1)

Recombinant Mouse Neuroserpin (Serpini1)

  • 中文名称：
    小鼠Serpini1重组蛋白
  • 货号：
    CSB-YP021089MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Serpini1重组蛋白
  • 货号：
    CSB-EP021089MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Serpini1重组蛋白
  • 货号：
    CSB-EP021089MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Serpini1重组蛋白
  • 货号：
    CSB-BP021089MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Serpini1重组蛋白
  • 货号：
    CSB-MP021089MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Serpini1
  • Uniprot No.：
  • 别名：
    Serpini1; Pi12; Spi17; Neuroserpin; Peptidase inhibitor 12; PI-12; Serine protease inhibitor 17; Serpin I1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    17-410
  • 氨基酸序列
    TGAT FPDETITEWS VNMYNHLRGT GEDENILFSP LSIALAMGMM ELGAQGSTRK EIRHSMGYEG LKGGEEFSFL RDFSNMASAE ENQYVMKLAN SLFVQNGFHV NEEFLQMLKM YFNAEVNHVD FSQNVAVANS INKWVENYTN SLLKDLVSPE DFDGVTNLAL INAVYFKGNW KSQFRPENTR TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE ISMMLALSRQ EVPLATLEPL LKAQLIEEWA NSVKKQKVEV YLPRFTVEQE IDLKDILKAL GVTEIFIKDA NLTAMSDKKE LFLSKAVHKS CIEVNEEGSE AAAASGMIAI SRMAVLYPQV IVDHPFLYLI RNRKSGIILF MGRVMNPETM NTSGHDFEEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).
  • 基因功能参考文献：
    1. The results of this identify neuroserpin as a modulator of synaptic plasticity, and point to a role for neuroserpin in learning and memory. PMID: 29142062
    2. the protective effect of neuroserpin maybe independent from its canonical interaction with a tissue-type plasminogen activator PMID: 26176694
    3. Brain metastatic cells from lung cancer and breast cancer express high levels of anti-plasminogen activator (PA) serpins, including neuroserpin and serpin B2, to prevent plasmin generation and its metastasis-suppressive effects. PMID: 24581498
    4. Data indicate that the neuroprotective effect of neuroserpin is due to inhibition of plasmin-mediated excitotoxin-induced cell death and is independent of neuroserpin's ability to inhibit tissue plasminogen activator activity. PMID: 20864675
    5. Neuroserpin reduces microglial activation and, therefore, plasminogen activator levels; it has a neuroprotective role after focal ischemic stroke. PMID: 11922137
    6. Neuroserpin mRNA is widely expressed in neuronal cells in the primary visual cortex during normal development as well as in the adult mouse. PMID: 12752785
    7. Our results implicate neuroserpin in the regulation of emotional behavior through a mechanism that is at least in part independent of tissue type plasminogen activator activity PMID: 12837630
    8. neuroserpin levels appear to be carefully regulated by LRP and an unidentified cofactor, and this pathway may be critical for maintaining the balance between proteases and inhibitors PMID: 14522960
    9. Altogether, these data suggest that an overexpression of neuroserpin in the brain parenchyma might limit the deleterious effect of tPA on NMDA receptor-mediated neuronal death, which occurs following experimental ischemia. PMID: 16209928
    10. Transgenic mice overexpressing neuroserpin have decreased plasminogen activators in sciatic nerve and spinal cord, confirming a role for neuroserpin in the evolution of a neurodegenerative disease. PMID: 17035547
    11. the existence of an AMH-dependent signalling pathway in the brain leading to an overexpression of the serine-protease inhibitor, neuroserpin, and neuronal survival PMID: 18796535
    12. Mutation-, aging-, and gene dosage-dependent accumulation of neuroserpin (G392E) in endoplasmic reticula and lysosomes of neurons in transgenic mice PMID: 18940798

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  • 亚细胞定位：
    Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Perikaryon.
  • 蛋白家族：
    Serpin family
  • 组织特异性：
    Detected in neurons in embryonic brain cortex (at protein level). During embryonic development mostly expressed in CNS. In adult expressed in brain and much less in spinal cord, heart, kidney and testis.
  • 数据库链接：

    KEGG: mmu:20713

    STRING: 10090.ENSMUSP00000029423

    UniGene: Mm.41560