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  4. Recombinant Mouse Neurturin (Nrtn)

Recombinant Mouse Neurturin (Nrtn)

  • 货号：
    CSB-YP016095MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP016095MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP016095MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP016095MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP016095MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nrtn
  • Uniprot No.：
  • 别名：
    Nrtn; Neurturin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    96-195
  • 氨基酸序列
    PGARP CGLRELEVRV SELGLGYTSD ETVLFRYCAG ACEAAIRIYD LGLRRLRQRR RVRRERARAH PCCRPTAYED EVSFLDVHSR YHTLQELSAR ECACV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
  • 基因功能参考文献：
    1. These results indicate that NRTN contributes to an increase in the epidermal density of nonpeptidergic nerves in the imiquimod-induced psoriasis model, and this increase may be a factor in chronic itch. PMID: 28825602
    2. NRTN causes presynaptic and postsynaptic restoration of the nigrostriatal dopaminergic system after a 6-OHDA-induced chronic lesion. PMID: 29176874
    3. identified IFNg, Neurturin (Nrtn), and glial-derived neurotrophic factor (GDNF) as ligands with unexpected roles in promoting neurogenic differentiation of Neural Precursor Cells in vivo. PMID: 27545711
    4. These results demonstrate the potential roles of different functional groups of sensory neurons in the behavioral changes observed in mice overexpressing cutaneous neurturin and highlight the importance of neurturin in regulating cutaneous afferent response properties. PMID: 28031403
    5. Deletion of neurturin impairs cholinergic innervation of the heart and the baroreflex response in early postnatal development. PMID: 27162260
    6. Our findings support the hypothesis that NTN could modulate the allergic inflammation in different mouse asthma models. PMID: 25595789
    7. NTN inactivation enhances androgen sensitivity in reproductive and neuroendocrine tissues. PMID: 23678134
    8. the expression level of NRTN in the skin modulates gene expression in cutaneous sensory afferents and behavioral sensitivity to thermal, chemical, and mechanical stimuli. PMID: 23365243
    9. Findings provide evidence for a dampening role of NTN on allergic inflammation and AHR in a murine model of asthma. PMID: 21508262
    10. Transduction-function role for GFR alpha2/neurturin signalling in a specific class of sensory neurons. PMID: 12433948
    11. This study revealed the complexity of postnatal maturation of urogenital innervation, with each organ showing a distinct chronology of innervation and different requirement for neurturin. PMID: 18175352
    12. Neurturin-mediated Ret signaling is critical to normal retinal development and function. PMID: 18417692
    13. TGF-beta with neurturin and persephin are required for the induction of dopaminergic neurons, whereas GDNF is required for regulating and/or maintaining a differentiated neuronal phenotype PMID: 18420832
    14. Report structural and functional cardiac cholinergic deficits in adult neurturin knockout mice. PMID: 19176599

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family, GDNF subfamily
  • 组织特异性：
    Widespread distribution.
  • 数据库链接：

    KEGG: mmu:18188

    STRING: 10090.ENSMUSP00000046512

    UniGene: Mm.8074