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  4. Recombinant Mouse Nuclear pore glycoprotein p62 (Nup62)

Recombinant Mouse Nuclear pore glycoprotein p62 (Nup62)

  • 货号：
    CSB-YP714362MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP714362MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP714362MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP714362MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP714362MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Nup62; Nuclear pore glycoprotein p62; 62 kDa nucleoporin; Nucleoporin Nup62
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-526
  • 氨基酸序列
    SGFNFGGTG APAGGFTFGT AKTATTTPAT GFSFSASGTG TGGFNFGTPS QPAATTPSTS LFSLTTQTPT TQTPGFNFGT TPASGGTGFS LGISTPKLSL SNAAATPATA NTGSFGLGSS TLTNAISSGS TSNQGTAPTG FVFGSSTTSA PSTGSTGFSF TSGSASQPGA SGFSLGSVGS SAQPTALSGS PFTPATLVTT TAGATQPAAA APTAATTSAG STLFASIAAA PASSSATGLS LPAPVTTAAT PSAGTLGFSL KAPGAAPGAS TTSTTTTTTT TTTTAAAAAA STTTTGFALS LKPLVSAGPS SVAATALPAS STAAGTATGP AMTYAQLESL INKWSLELED QERHFLQQAT QVNAWDRTLI ENGEKITSLH REVEKVKLDQ KRLDQELDFI LSQQKELEDL LSPLEESVKE QSGTIYLQHA DEEREKTYKL AENIDAQLKR MAQDLKDIIE HLNMAGGPAD TSDPLQQICK ILNAHMDSLQ WVDQSSALLQ RRVEEASRVC EGRRKEQERS LRIAFD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown.
  • 基因功能参考文献：
    1. Nucleoporins 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells. PMID: 30022050
    2. Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress PMID: 25349423
    3. Nup62 depletion leads to the appearance of multinucleated cells and induces the formation of multipolar centrosomes, centriole synthesis defects, dramatic spindle orientation defects, and centrosome component rearrangements that impair cell bi-polarity. PMID: 24107630
    4. ORP8 was shown to compete with Exo70 for interaction with NUP62, and NUP62 knockdown abolished the migration enhancement of ORP8-silenced cells, suggesting that the endogenous ORP8 suppresses migration via binding to NUP62. PMID: 22683860
  • 亚细胞定位：
    Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    Nucleoporin NSP1/NUP62 family
  • 数据库链接：

    KEGG: mmu:18226

    STRING: 10090.ENSMUSP00000056785

    UniGene: Mm.2565