Recombinant Mouse Nuclear respiratory factor 1 (Nrf1)

1. mRNA and protein levels of Nrf1D were detected to varying extents in hemopoietic and somatic tissues. Nrf1D-derived isoforms were present in blood plasma. PMID: 30261697
2. Study identifies the endoplasmic reticulum (ER)-bound transcription factor nuclear factor erythroid 2 related factor-1, Nrf1/Nfe2L1, as a critical mediator of this process and shows that Nrf1 directly binds to and specifically senses cholesterol in the ER through a defined domain and that cholesterol regulates Nrf1 turnover, processing, localization, and activity. PMID: 29149604
3. data highlight a precise crosstalk between transcriptional regulation by NRF1 and epigenetic modulation during germ cell development and unequivocally demonstrate a novel role of NRF1 in spermatogenesis PMID: 28754714
4. Nrf1 knockdown suppressed the death of ubiquitin-deficient N2a cells upon exposure to As(III). Therefore, the levels of p65-Nrf1 may play an important role in the maintenance of cell viability under oxidative stress induced by As(III). PMID: 28237703
5. findings suggest that neurodegeneration in Nrf1 NKO mice may stem from the dysfunction of the ubiquitin-mediated regulation of neuronal proteins PMID: 28088524
6. Our findings demonstrate that DEE and a fraction derived from this extract exerts anti-inflammatory effects through Nrf2dependent HO-1 expression PMID: 26647788
7. NRF1 (nuclear respiratory factor 1) is a methylation-sensitive transcription factor; in the absence of DNA methylation, NRF1 binds to new sites and induces aberrant transcription PMID: 26675734
8. Nrf1 plays critical roles in regulating glucose metabolism, mitochondrial function, and insulin secretion, suggesting that Nrf1 may be a novel target to improve the function of insulin-secreting beta-cells. PMID: 25556857
9. lysine-specific demethylase 1 promotes oxidative phosphorylation in white adipose tissue, in cooperation with Nrf1. PMID: 24912735
10. Results show that Nrf1 may not be directly responsible for the loss of Nrf2-dependent inducibility of antioxidant and cytoprotective genes observed in aged animals. PMID: 24024152
11. Nrf1 controls both the fatty acid and the cystine/cysteine content of hepatocytes by participating in an elaborate regulatory network. PMID: 25092871
12. Data indicate both Nrf1a and Nrf1b isoforms transcripts were detected in different mouse and human cell lines, and in various mouse tissues. PMID: 23144760
13. During fetal myogenesis, Pitx2/3 control this redox state through the regulation of Nrf1 and of antioxidant pathways. PMID: 24871946
14. NST-adjoining TADs are partially repartitioned out of membranes into the cyto/nucleoplasmic side, where Nrf1 is subject to deglycosylation and/or proteolysis to generate 95-kDa and 85-kDa isoforms PMID: 23774320
15. NRF-2 and NRF-1 operate in a concurrent and parallel manner in mediating the tight coupling between energy metabolism and neuronal activity at the molecular level. PMID: 23085505
16. Nrf1 binds to the antioxidant response elements (AREs) in regulatory regions of the Lipin1 and PGC-1beta genes and the binding of Nrf1 to the AREs activates reporter gene transcription. PMID: 22586274
17. these results clearly suggest that both beta-TrCP- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 to maintain cellular homeostasis. PMID: 21911472
18. These results show that Nrf1 sustains the CNS homeostasis through regulating target genes distinct from those regulated by Nrf2. PMID: 21554501
19. Nrf1 is a key transcriptional regulator required for the expression of proteasomal genes in neurons and perturbations of Nrf1 function may contribute to the pathogenesis of neurodegenerative diseases PMID: 21536885
20. Study observed that Nrf1 overexpression stimulated cell proliferation, apoptosis, and cytokine expression. Prolonged Nrf1 induced an adipokine expression profile of insulin resistant adipocytes. PMID: 21053274
21. Findings indicate that TLR4-dependent NFkappaB and CREB activation co-regulate the NRF1 promoter with NFkappaB intronic enhancement and redox-regulated nuclear translocation, leading to downstream target-gene expression. PMID: 20587593
22. NRF-1 overexpression sensitizes cells to apoptosis on serum depletion PMID: 12533512
23. The Nrf1 metabolic pathway is the major regulator of genes that function in the mitochondrion. PMID: 12849846
24. NRF-1 and NRF-2 prove to be the two key bigenomic coordinators for transcriptional regulation of all cytochrome c oxidase subunits in neurons PMID: 18077450
25. beneficial effects of Sirt1 are due to at least two mechanisms: induction of antioxidant proteins MnSOD and Nrf1 PMID: 18599449
26. In this study they asked whether the interactions between USF1/USF2 and E-Box and Nrf1 and GC-Box in the brain of mouse are influenced by postnatal age and what link it has with reported age-related decrease in the expression of Fmr-1 gene. PMID: 18782566
27. Accumulation of nuclear NRF-1 protein leads to gene activation for heart mitochondrial biogenesis. PMID: 18845810
28. NRF-1 can also directly interact with poly(ADP-ribose) polymerase 1 (PARP-1) and co-purify the PARP-1.DNA-PK.Ku80.Ku70.topoisomerase IIbeta-containing protein complex. PMID: 19181665

显示更多

收起更多

KEGG: mmu:18181

STRING: 10090.ENSMUSP00000065568

UniGene: Mm.259258