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  4. Recombinant Mouse Oligodendrocyte transcription factor 1 (Olig1)

Recombinant Mouse Oligodendrocyte transcription factor 1 (Olig1)

  • 货号：
    CSB-YP016328MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP016328MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP016328MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP016328MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP016328MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Olig1
  • Uniprot No.：
  • 别名：
    Olig1; Oligodendrocyte transcription factor 1; Oligo1; Oligodendrocyte-specific bHLH transcription factor 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-260
  • 氨基酸序列
    MYYAISQARV NAAPATMLRP QRPGDVQLGA SLYELVGYRQ PPISSSSSSS SSTASLLPKP AREKAEAPLA EPRGPAPESG GARADAKEEQ QQQQLRRKIN SRERKRMQDL NLAMDALREV ILPYSAAHCQ GAPGRKLSKI ATLLLARNYI LLLGSSLQEL RRALGDGAGP AAPRLLLAGL PLLAAAPGSV LLAPGAVGPP ETLRPTKYLS LALDEPPCGQ FSLPAGGAGS PGLCSCAVCK FPHLVPAGLG LAAVQAQFSK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.
  • 基因功能参考文献：
    1. found that many of the Olig2-bound sites were associated with genes with biological processes corresponding to OL differentiation (Nkx2.2, Nkx6.2, and Sip1), myelination and ensheathment (Mbp, Cldn11, and Mobp), as well as cell cycle and cytoskeletal regulation PMID: 29049317
    2. Olig1 begins to be expressed at the ventral domain of the otocyst at embryonic day (E) 9.5, and Olig1 expression in the epithelium of the developing inner ear persists to E15.5. PMID: 25778822
    3. These studies establish that acetylation of Olig1 regulates its chromatin dissociation and subsequent translocation to the cytoplasm and is required for its function in oligodendrocyte maturation. PMID: 26631469
    4. The current study demonstrates a unique role for Olig1 in promoting oligodendrocyte progenitor cell commitment, differentiation, and subsequent myelination primarily in brain, but not spinal cord. PMID: 25762682
    5. Our findings support the original conclusion that Olig1 plays a minor and non-essential role in oligodendrocyte development. PMID: 24423059
    6. The results of this study establish Olig1 as an essential repressor of Dlx1/2 and interneuron production in developing mammalian brain. PMID: 24507192
    7. Olig1 is a Smad cofactor involved in TGF-beta-induced cell motility PMID: 23720758
    8. Our results suggest a novel role for a phosphorylated cytosolic Olig1 in membrane expansion and maturation of oligodendrocytes. PMID: 22639060
    9. Olig1function is required for the remyelination potential of neural stem cells after transplant, through specification and/or maintenance of oligodendroglial identity. PMID: 22449475
    10. 10% of Olig1 deficient mice delayed onset of experimental autoimmune encephalomyelitis. PMID: 20927333
    11. In the spinal cord, Olig1, Olig2 and proneural genes comprise a combinatorial code for the specification of neurons, astrocytes, and oligodendrocytes. PMID: 11955447
    12. Olig1 has a role in inducing differentiation of neural stem cells into oligodendrocyte progenitor cells PMID: 15536179
    13. findings show that Olig1 function in mice is required not to develop the brain but to repair it; demonstrated a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis PMID: 15604411
    14. Olig1 regulates transcription of the major myelin-specific genes, Mbp, Plp1, and Mag, and suppresses expression of a major astrocyte-specific gene, Gfap. Olig1 is a central regulator of oligodendrocyte myelinogenesis in brain. PMID: 15703389
    15. The expression of nuclear Olig1 was inhibited when mouse oligodendrocyte progenitor cells were cultured in the absence of insulin. PMID: 18621485
    16. Data show that both Olig1 transcription and Olig1 protein expression are downregulated during oligodendrocyte progenitor cell differentiation. PMID: 18628665

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed specifically in brain.
  • 数据库链接：

    KEGG: mmu:50914

    STRING: 10090.ENSMUSP00000061408

    UniGene: Mm.39300