Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Oligodendrocyte transcription factor 2 (Olig2)

Recombinant Mouse Oligodendrocyte transcription factor 2 (Olig2)

  • 中文名称：
    小鼠Olig2重组蛋白
  • 货号：
    CSB-YP880634MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Olig2重组蛋白
  • 货号：
    CSB-EP880634MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Olig2重组蛋白
  • 货号：
    CSB-EP880634MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Olig2重组蛋白
  • 货号：
    CSB-BP880634MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Olig2重组蛋白
  • 货号：
    CSB-MP880634MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Olig2
  • Uniprot No.：
  • 别名：
    Olig2; Oligodendrocyte transcription factor 2; Oligo2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-323
  • 氨基酸序列
    MDSDASLVSS RPSSPEPDDL FLPARSKGGS SSGFTGGTVS SSTPSDCPPE LSSELRGAMG ASGAHPGDKL GGGGFKSSSS STSSSTSSAA TSSTKKDKKQ MTEPELQQLR LKINSRERKR MHDLNIAMDG LREVMPYAHG PSVRKLSKIA TLLLARNYIL MLTNSLEEMK RLVSEIYGGH HAGFHPSACG GLAHSAPLPT ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS ASLPGSGLSS VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG GSGGFQHWGG MPCPCSMCQV PPPHHHVSAM GAGTLPRLTS DAK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
  • 基因功能参考文献：
    1. Cuprizone-induced schizophrenia-like symptoms involved olig2 upregulation. The silence of olig2 could prevent changes, likely through regulating MBP, CNPase, and GFAP expressions. PMID: 28989170
    2. transient hypoxia at P7 altered the expression of Olig1 and Nkx2.2, resulting in delayed myelination in the external capsule. PMID: 28546087
    3. Functionally, deletion of Olig2 alone results in a preferential reduction of Purkinje cells in the cerebellum, which is likely mediated by decreased neuronal generation from their cerebellar ventricular zone progenitors. PMID: 27469598
    4. Olig2 is down-regulated in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus. PMID: 26631080
    5. phosphorylation of the motif itself serves as a template to prime phosphorylation of additional serines and creates a highly charged "acid blob" in the amino terminus of Olig2. PMID: 28355568
    6. OLIG2 modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR) or platelet-derived growth factor receptor alpha. PMID: 27626655
    7. the dynamic interplay between HMGNs and H1 in chromatin epigenetically regulates the expression of OLIG1&2, thereby affecting oligodendrocyte development and myelination, and mouse behavior. PMID: 27923998
    8. Olig2 was significantly upregulated and transcriptionally targeted the Gpr17 locus PMID: 27733608
    9. Brg1 represses Olig2 expression and the specification of oligodendrocyte progenitors, but is required for OPC differentiation and oligodendrocyte maturation PMID: 27067865
    10. Data show that oligodendrocyte transcription factor 2 (Olig2) deletion causes platelet-derived growth factor receptor (PDGFR) downregulation and reciprocal epidermal growth factor receptor (EGFR) upregulation. PMID: 27165742
    11. This study suggests that Olig2 misexpression in neural stem cells elicits neurogenesis defects and neuronal cell death, which may contribute to developmental disorders including Down syndrome PMID: 25747816
    12. OLIG2 is a multifunctional regulator of neural stem cell self-renewal PMID: 25294244
    13. Olig2 expression is localized to the cochleovestibular ganglia from E12.5 through E14.5 PMID: 25778822
    14. Olig2 overexpression accelerates the differentiation of mouse embryonic stem cells into oligodendrocyte progenitor cells in vitro. PMID: 25200136
    15. This study demonstrated that that OLIG2 overexpression in oligodendrocyte progenitor cells might be a possible therapeutic mechanism for enhancing myelin repair. PMID: 25564492
    16. Results from expression pattern suggests that Olig2 may have an important role in the early stage of Purkinje cell development. PMID: 24594479
    17. Prox1 controls binary fate decisions between motor neurons and V2 interneurons in progenitor cells via direct repression of Olig2 gene regulatory elements PMID: 25411508
    18. Phosphorylated Olig2 is preferentially localized to a transcriptionally active compartment for regulation of gene expression. PMID: 24948806
    19. Olig2 is involved in correct formation of the prethalamus. PMID: 24803655
    20. Notch signaling might promote proliferation and differentiation of reactive astrocytes through regulation of nucleo-cytoplasmic translocation of Olig2. PMID: 23396245
    21. Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. PMID: 23492777
    22. The results of this study suggested a stage-specific regulatory role for Olig2, mediated by Olig1 that conveys opposing functions on the differentiation and maturation of oligodendrocytes. PMID: 23658182
    23. This study demonistrated that in chronic demyelinated lesions more Olig2-lineage cells are produced as part of the repair process, but their processes degenerate after maturation. PMID: 23172790
    24. Olig2 protein has the ability to permeate the cell membrane without the addition of a protein transduction domain (PTD), similar to other basic helix-loop-helix transcription factors such as MyoD and NeuroD2. PMID: 23022191
    25. Study finds that the oligodendrocyte-lineage determination factor Olig2 transcriptionally prepatterns the chromatin-remodeling factor Smarca4/Brg1 to the enhancer elements to control oligodendrocyte differentiation. PMID: 23332759
    26. Olig2 is strictly required to maintain the malignancy of oligodendroglioma cells. PMID: 22514120
    27. The findings indicated that NG2+ polydendrocytes in the embryonic and early postnatal brain exhibit developmental fate switch from oligodendrocytes to astrocytes in vivo upon removal of Olig2. PMID: 22627280
    28. The Olig2 can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching. PMID: 21624811
    29. analysis of conserved and non-conserved functional elements at the Olig1 and Olig2 locus PMID: 21206754
    30. Data show that Olig2 affects a key posttranslational modification of p53 in both normal and malignant neural progenitors and thereby antagonizes the interaction of p53 with promoter elements of multiple target genes. PMID: 21397859
    31. In the phosphorylated state, Olig2 maintains antineural (i.e., promitotic) functions that are reflected in human glioma cells and in a genetically defined murine model of primary glioma. PMID: 21382551
    32. We conclude that S147 phosphorylation of OLIG2, possibly by protein kinase A, is required for motor neuron but not oligodendrocyte precursor genesis and propose that dephosphorylation triggers the switch. PMID: 21382552
    33. the percentage of virus-infected cells with Na(+) currents was increased by inhibition of the repressor function of Olig2 and by overexpression of Pax6 PMID: 21051674
    34. Olig1 and Olig2, two genes that are triplicated in Down syndrome were overexpressed in a widely used model of Down syndrome PMID: 20639873
    35. Olig2 is expressed in the ventral thalamus of developing mice PMID: 11960707
    36. Olig2 is an essential transcriptional regulator in motoneuron and oligodendrocyte development PMID: 12121626
    37. Both Olig2 and MASH1 are required topromoter Shh-mediated forebrain GABAergic neuronal/oligodendrocyte lineage restrictionand exhibit complementary & cooperative factor interactions. PMID: 12461181
    38. the OLIG2 protein in the nuclei of neural precursor cells disappears in accordance with astrocytic differentiation during culture with leukemia inhibitory factor PMID: 14576772
    39. Nkx6.1 controls oligodendrocyte development in the developing spinal cord, possibly by regulating Olig gene expression in the ventral neuroepithelium PMID: 14602683
    40. Interference with Olig2 in neurospheres revealed its role in self-renewal during expansion and for the generation of neurons and oligodendrocytes during differentiation. PMID: 15080895
    41. Olig2+ progenitor cells have features of glial cells but are able to divide rapidly for at least 1 month while still expressing Olig2. The cells differentiate into astrocyte-like and oligodendrocyte-like cells when switched to serum-containing medium. PMID: 15139016
    42. AKT-stimulated export of OLIG2 from the nucleus of neural stem cells is essential for astrocyte differentiation. PMID: 15452140
    43. Olig2/Ngn2 ratio in motor neuron progenitor cells serves as a gate for timing proper gene expression during the development. PMID: 15655114
    44. results indicate that Olig2 serves a critical role in pan-glial versus neuronal fate decisions in subventricular zone (SVZ) progenitors, making it the first intrinsic fate determinant shown to operate in the early postnatal SVZ PMID: 16093378
    45. the introduced overexpression of Olig2 could induce the development of fully mature oligodendrocytes expressing the transcription factor Nkx2.2 and all major myelin-specific proteins PMID: 16253982
    46. Olig2 is a repressor of neurogenesis in cells reacting to brain injury. PMID: 16330768
    47. Olig2(+) progenitors do not maintain neurogenic potential into the period of gliogenesis and therefore do not self-renew PMID: 16432183
    48. These results suggest that olig2 is involved in the maintenance of the undifferentiated state of retinal progenitor cells. PMID: 16514356
    49. When the Olig2-expressing cells at E12.5 were permanently modified to express the lacZ or EGFP gene, the cells marked by reporter gene expression were widely distributed in the basal forebrain by E18.5, some of which expressed neuronal markers. PMID: 16537079
    50. motoneurons and oligodendrocyte progenitors are derived from the Olig2+ progenitors in the restricted domain of the ventral ventricular zone of the embryonic spinal cord PMID: 16581057

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
  • 组织特异性：
    Expressed specifically in the brain.
  • 数据库链接：

    KEGG: mmu:50913

    STRING: 10090.ENSMUSP00000036797

    UniGene: Mm.37289