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  4. Recombinant Mouse Orexigenic neuropeptide QRFP (Qrfp)

Recombinant Mouse Orexigenic neuropeptide QRFP (Qrfp)

  • 货号：
    CSB-YP807004MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP807004MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP807004MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP807004MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP807004MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Qrfp
  • Uniprot No.：
  • 别名：
    Qrfp; Orexigenic neuropeptide QRFP; P518) [Cleaved into: QRF-amide; Neuropeptide RF-amide; Pyroglutamylated arginine-phenylalanine-amide peptide)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    80-122
  • 氨基酸序列
    Q DGSSEAAGFL PADSEKASGP LGTLAEELSS YSRRKGGFSF RF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stimulates feeding and grooming behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland.
  • 基因功能参考文献：
    1. QRFP is an important downstream mediator of the arcuate nucleus and regulates feeding behavior, mood, wakefulness and activity. PMID: 27835635
    2. 26RFa attenuates the hyperglycemia induced by a glucose load, potentiates insulin sensitivity, and increases plasma insulin concentrations. PMID: 25858563
    3. Macrophage-conditioned medium containing increased amounts of QRFP preserves adipogenesis in adipocytes. PMID: 24284825
    4. The present review discusses the role of QRFP in the regulation of feeding behavior, with emphasis on the intake of dietary fat. PMID: 23979792
    5. Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis. PMID: 20534693
    6. Characterization and tissue distribution of SP9155 (GPR103) ligand. PMID: 12714592
    7. P518/26RFa is a neuropeptide that stimulates food intake in mice. PMID: 15891009
    8. Qrfp polymorphisms is associated with osteopenia PMID: 17869477

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    RFamide neuropeptide family
  • 组织特异性：
    Expressed in the brain with highest levels in the periventricular hypothalamic nucleus and lateral hypothalamic areas. Expressed at moderate levels in the adrenal gland, eye, heart, intestine, liver, lung, kidney, mesenteric lymph node, ovary, placenta, P
  • 数据库链接：

    KEGG: mmu:227717

    STRING: 10090.ENSMUSP00000055746

    UniGene: Mm.185027