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  4. Recombinant Mouse Ornithine decarboxylase antizyme 1 (Oaz1)

Recombinant Mouse Ornithine decarboxylase antizyme 1 (Oaz1)

  • 中文名称：
    小鼠Oaz1重组蛋白
  • 货号：
    CSB-YP016245MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Oaz1重组蛋白
  • 货号：
    CSB-EP016245MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Oaz1重组蛋白
  • 货号：
    CSB-EP016245MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Oaz1重组蛋白
  • 货号：
    CSB-BP016245MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Oaz1重组蛋白
  • 货号：
    CSB-MP016245MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Oaz1
  • Uniprot No.：
  • 别名：
    Oaz1; Oaz; Ornithine decarboxylase antizyme 1; ODC-Az
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-227
  • 氨基酸序列
    VKSSLQRIL NSHCFAREKE GDKRSATLHA SRTMPLLSQH SRGGCSSESS RVALNCCSNL GPGPRWCSDV PHPPLKIPGG RGNSQRDHSL SASILYSDER LNVTEEPTSN DKTRVLSIQS TLTEAKQVTW RAVWSGGGLY IELPAGPLPE GSKDSFAALL EFAEEQLQAD HVFICFPKNR EDRAALLRTF SFLGFEIVRP GHPLVPKRPD ACFMVYTLER EDPGEED
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
  • 基因功能参考文献：
    1. Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ). PMID: 26093026
    2. we have generated transgenic mice overexpressing mouse antizyme 1 gene under its own regulatory sequences PMID: 24174210
    3. Ornithine decarboxylase antizyme expression reduces tumor incidence, multiplicity and size even in the absence of p53. PMID: 23222816
    4. The activity of AZ1 was low in the virgin and involuting stages, but increased markedly during late pregnancy and early lactation. PMID: 19997757
    5. Testosterone treatment enhanced AZ1 and N1-SSAT mRNA levels in a time-dependent manner PMID: 12709396
    6. antizyme and glycosaminoglycans have roles in polyamine transport PMID: 16263714
    7. Az-1 has a central and meaningful role in modulation of polyamine homeostasis, and in regulating cellular proliferation and transformation properties. PMID: 16568078
    8. required for the proper formation of forebrain and hindbrain midline structures PMID: 17524391
    9. The data-driven docking results suggest that both proteins occupy the same binding site on Az1, with Az1 binding within a large groove in antizyme inhibitor (AzI) and Ornithine Decarboxylase (ODC). PMID: 19465028
    10. antizyme expression requires programmed, ribosomal frameshifting PMID: 7813017

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  • 蛋白家族：
    ODC antizyme family
  • 数据库链接：

    KEGG: mmu:18245

    STRING: 10090.ENSMUSP00000137400

    UniGene: Mm.398119