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  4. Recombinant Mouse Oxytocin receptor (Oxtr), partial

Recombinant Mouse Oxytocin receptor (Oxtr), partial

  • 货号：
    CSB-YP017316MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP017316MO1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP017316MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP017316MO1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP017316MO1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Oxtr; Oxytocin receptor; OT-R
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
  • 基因功能参考文献：
    1. Repression of OXTR signaling acutely modulates social interaction and sensory response profiles. PMID: 29231812
    2. Results show that OTR activation might constitute one of the neural substrate that is involved involved in the facilitative mechanisms to restore the sexual olfactory preferences of sexually naive Tph2-/- female mice. PMID: 29470551
    3. depressive-like behavior alters oxytocin receptor (OxtR) and arginine vasopressin receptor type 1a (AvpR1a) gene expression in the hippocampus (HC) of male mice. PMID: 27525673
    4. Chemogenetic activation of Oxtr(PBN) neurons robustly suppressed noncaloric fluid intake, but did not decrease food intake after fasting or salt intake PMID: 29184212
    5. Binding activity of OXTR in neonatal mice. PMID: 28235051
    6. Findings suggest that OXTR is an acute-phase protein and that its increased expression is regulated by NF-kappaB and functions to attenuate cellular inflammatory responses in macrophages. PMID: 28049625
    7. Results provide evidence that the oxytocin system contributes to the regulation of ethanol drinking and sensitivity and position OxtR as a central molecular mediator of ethanol's effects within the mesolimbic system, suggest that OxtR manipulation may be a relevant strategy to address ethanol use disorders. PMID: 27306084
    8. Data suggest that the study might contribute to the monosynaptic analysis of neuronal circuits and to the optogenetic analysis of neurons expressing oxytocin receptor (OXTR). PMID: 26442453
    9. Our results suggest that microglial abnormality is a potential mechanism of the development of Oxt/Oxtr mediated ASD-like phenotypes. PMID: 26926566
    10. The results suggest that oxytocin receptor is required for conditioned effects of an ethanol-associated social stimulus PMID: 26282397
    11. This study identify highly specialized roles of lateral septal mGluR5 and Oxtr in the the regulation of discrete social behaviors, and suggest that deficits in social interactions. PMID: 25824423
    12. OTR-null residents exhibited greater aggression toward intruders of the same strain compared to OTR wild-type or heterozygous residents PMID: 24929102
    13. Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxiety-like behavior PMID: 25677455
    14. Oxtr signaling is crucial for entrainment of odor to social cues but is dispensable for entrainment to nonsocial cues. Oxytocin conveys saliency of social stimuli to sensory representations in the piriform cortex during odor-driven social learning. PMID: 26139372
    15. Study used the oxytocin analog Carbetocin and nucleus accumbens viral-mediated overexpression to assess the role of OxtR in the acquisition, extinction, and reinstatement of ethanol-induced conditioned place preference PMID: 25449413
    16. Oxytocin's effect on osteoblast differentiation is mediated by and dependent on the internalization of Oxtrs and their translocation to the nucleus, facilitated by successive interactions with beta-arrestins, Rab5, Kpnb1), and Tnpo1. PMID: 25378700
    17. Silencing of interneurons that express the oxytocin receptor in the medial prefrontal cortex (mPFC) of female mice resulted in loss of social interest in male mice specifically during the sexually receptive phase of the estrous cycle. PMID: 25303526
    18. Impairments in the initiation of maternal behavior in oxytocin receptor knockout mice PMID: 24892749
    19. Oxytocin elicits satiety through both central and peripheral oxytocin receptors. PMID: 24877632
    20. Collectively, our results suggest that brain region-specific expression of the mouse Oxtr gene is epigenetically regulated by DNA methylation of its promoter. PMID: 24275011
    21. Early interactions with mother and peers independently build adult social skills and shape BDNF and oxytocin receptor brain levels PMID: 22910688
    22. This study is the first to demonstrate that the central oxytocin/oxytocin receptor system plays important roles in the regulation of body temperature homeostasis. PMID: 24002032
    23. This study demonistrated that Fear-enhancing effects of septal oxytocin receptors. PMID: 23872596
    24. The Oxtr(+/-) mouse is a unique animal model for investigating how partial loss of the Oxtr gene impair social interactions. PMID: 22967062
    25. LPS increased COX-2, connexin 43, and oxytocin receptor expression in uterus. PMID: 22676250
    26. It was shown that male aggression is heightened in oxytocin receptor -/- mice, and that differential activation in the medial amygdala, and possibly the lateral septum, may be contributing to the heightened aggression. PMID: 22609339
    27. the profile for Oxtr KO mice, including consistent social deficits, and reduced levels of communication, models multiple components of the autism spectrum disorders phenotype PMID: 22100185
    28. We consider the processes by which experience can affect oxytocin receptor binding, and what is known about the directionality of experience effects on oxytocin receptors--REVIEW PMID: 22245313
    29. we do find evidence for the role of OTR in predicting maternal behavior in mice PMID: 22300676
    30. Mice that have Oxt receptor loss restricted to the forebrain that begins postweaning have a reduction in freezing behavior during acquisition, as well as during context and cue retention. PMID: 21668734
    31. Results suggest that variations of estrogen alpha/beta receptor levels are associated with differences in social interaction through the OT and AVP systems, by upregulating gene expression for those peptides and the oxytocin and vasopressin 1a receptors. PMID: 21749489
    32. investigation of regulation of ghrelin secretion in the MGN3-1 cell line: evidence that oxytocin and oxytocin receptors are involved PMID: 21521750
    33. beta-arrestin is a multifunctional scaffold protein that mediates both desensitization of the OXTR, leading to decreases in uterine contractility PMID: 21139074
    34. Inflammatory cytokines modulate the expression of functional oxytocin receptors in airway smooth muscle. PMID: 20670427
    35. results show that in mast cells ovarian hormones modulate OTR but not serotonin transporter(SERT) expression; oxytocin action on 5HT uptake depends on OTRs expressed; signaling between OTR and the SERT is mediated through activation of protein kinase C. PMID: 12374464
    36. Increases in myometrial oxytocin receptor and estrogen receptor alpha expression in late pregnant relaxin+/+ mice were attenuated in relaxin-/- mice. Probably mediated via activation of estrogen receptor-alpha. PMID: 12959965
    37. the present study has identified novel sites of oxytocin receptor expression in the mouse brain, suggesting additional functions of the oxytocinergic system PMID: 14596857
    38. These results suggest that oxytocin (OT)-induced uterine contraction is not regulated solely by the quantity of OT receptors in the non-pregnant mouse uterus. PMID: 15358162
    39. Myometrial OTRs were significantly decreased on gestation day 18.5 in relaxin (Rlx)-/- mice than in Rlx+/+ mice PMID: 15956692
    40. OXTR plays a critical role in regulating several aspects of social behavior, including aggression in males and maternal nurturing in females PMID: 16249339
    41. Oxytocin receptor-deficient mice developed late-onset obesity in mice. PMID: 18520999
    42. An investigation of various behaviours, most notably social recognition, in both oxytocin receptor containing and oxytoxin receptor knockout mice. PMID: 18655873
    43. ORE deficient mice display several aberrations in social behaviours, including male aggression, and mother-offspring interaction. PMID: 18655874
    44. Oxytocin may regulate serotonin release and exert anxiolytic effects via direct activation of oxytocin receptor expressed in serotonergic neurons of the raphe nuclei. PMID: 19228979
    45. We hypothesize that the Oxtr is involved in 'fine' intrastrain recognition, but is less important in 'broad' interstrain recognition. PMID: 19531157

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Vasopressin/oxytocin receptor subfamily
  • 数据库链接：

    KEGG: mmu:18430

    STRING: 10090.ENSMUSP00000051132

    UniGene: Mm.333310