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  4. Recombinant Mouse PDZ and LIM domain protein 4 (Pdlim4)

Recombinant Mouse PDZ and LIM domain protein 4 (Pdlim4)

  • 中文名称：
    小鼠Pdlim4重组蛋白
  • 货号：
    CSB-YP017735MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pdlim4重组蛋白
  • 货号：
    CSB-EP017735MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pdlim4重组蛋白
  • 货号：
    CSB-EP017735MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pdlim4重组蛋白
  • 货号：
    CSB-BP017735MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pdlim4重组蛋白
  • 货号：
    CSB-MP017735MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pdlim4
  • Uniprot No.：
  • 别名：
    Pdlim4; Ril; PDZ and LIM domain protein 4; LIM protein RIL; Reversion-induced LIM protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-330
  • 氨基酸序列
    MTHSVTLRGP SPWGFRLVGG RDFSAPLTIS RVHAGSKAAL AALCPGDLIQ AINGESTELM THLEAQNRIK GCHDHLTLSV SRPENKNWPS APDDKAQAHR IHIDPESQDC SPATSRRSSV SGISLEDNRS GLGSPYGQPP RLPVPHNGSS NEATLPAQMS ALHVSPPTSA DTARVLPRNR DCRVDLGSEV YRMLREPAEP TASEPKQSGS FRYLQGMLEA GEGGDRPGSG GPRNLKPAAS KLGAPLSGLQ GLPECTRCGH GIVGTIVKAR DKLYHPECFM CSDCGLNLKQ RGYFFLDERL YCENHAKARV KPPEGYDVVA VYPNAKVELV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons.
  • 基因功能参考文献：
    1. RIL C-terminus proper, but not the RIL LIM domain, can interact with protein tyrosine phosphatase BL PMID: 15663004
    2. PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells. PMID: 19212833
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, dendritic spine. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell junction, synapse, synaptosome.
  • 组织特异性：
    Expressed in several non-muscle tissues including lung, brain, ovary and uterus, and especially in epithelial cells on embryonic day 14 (E14). In the uterus, high expression in the glandular epithelium, but absent in the simple columnar epithelium lining
  • 数据库链接：

    KEGG: mmu:30794

    STRING: 10090.ENSMUSP00000018755

    UniGene: Mm.21830